{"created":"2023-06-19T09:12:52.869647+00:00","id":24793,"links":{},"metadata":{"_buckets":{"deposit":"a67f0863-ef46-4906-9f77-cfb1b8d882c7"},"_deposit":{"created_by":1,"id":"24793","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"24793"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024793","sets":["413:429"]},"author_link":["111446","111445","111447"],"item_18_alternative_title_22":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Molecular mechanisms of a multifunctional AAA protein, p97"}]},"item_18_alternative_title_23":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"タキノウ AAA タンパクシツ p97 ノ キノウ カイセキ : カク ドメイン ノ セイタイナイ キノウ ト セイカガクテキ キノウ"}]},"item_18_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-05-31","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_18_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Esaki, Masatoshi"}],"nameIdentifiers":[{"nameIdentifier":"111447","nameIdentifierScheme":"WEKO"}]}]},"item_18_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf"}]},"item_18_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"研究報告書","subitem_description_type":"Other"}]},"item_18_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"p97 は細胞内の様々な反応に関与している必須なAAA ATPase であり，優性進行性疾患である骨パジェット病と前頭側頭葉型認知症を伴う遺伝性封入体筋炎の原因因子である。p97 には2 つのAAA ドメインがあるが，疾患を引き起こす変異はN 末端側半分に集中している。本研究では，各ドメインのATPase 活性を失った変異体を作製し，その機\n能を調べた。その結果，C 末端側のAAA ドメインはp97 の機能に必須であり，その活性はN末端側のAAA ドメインによって調節されていることが分かった。","subitem_description_type":"Other"},{"subitem_description":"P97 is an essential AAA ATPase that is required for many cellular\nprocesses, and is identified as a causative gene for an autosomal dominant human disorder,\ninclusion body myopathy associated with Paget’s disease of the bone and frontotemporal\ndementia. P97 possesses two AAA domains, in which disease-related mutations are mostly\nfound in the N-terminal half. In this study, effects of mutations defective in ATPase\nactivity in each AAA domain on the function of yeast p97 were analyzed. In this result,\nit is found that the C-terminal AAA domain is essential for p97 functions, which is\nmodulated by the N-terminal AAA domain.","subitem_description_type":"Other"}]},"item_18_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学"}]},"item_18_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"464.2","subitem_subject_scheme":"NDC"}]},"item_18_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"1654036 bytes"}]},"item_18_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"研究報告書"}]},"item_18_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Research Paper"}]},"item_18_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_18_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"06"}]},"item_18_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_value":"平成20～21年度科学研究費補助金(若手研究(B))研究成果報告書　課題番号：20770106"}]},"item_18_text_80":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_text_value":"20770106"}]},"item_18_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"江崎, 雅俊"}],"nameIdentifiers":[{"nameIdentifier":"111445","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"KaYB20770106.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KaYB20770106.pdf","url":"https://kumadai.repo.nii.ac.jp/record/24793/files/KaYB20770106.pdf"},"version_id":"2aa2b9e9-5ab7-4b69-abe6-eb3d8b4cc5ff"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"AAA","subitem_subject_scheme":"Other"},{"subitem_subject":"ATPase","subitem_subject_scheme":"Other"},{"subitem_subject":"分子シャペロン","subitem_subject_scheme":"Other"},{"subitem_subject":"出芽酵母","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"多機能AAAタンパク質p97の機能解析 : 各ドメインの生体内機能と生化学的機能","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"多機能AAAタンパク質p97の機能解析 : 各ドメインの生体内機能と生化学的機能"}]},"item_type_id":"18","owner":"1","path":["429"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-06-13"},"publish_date":"2011-06-13","publish_status":"0","recid":"24793","relation_version_is_last":true,"title":["多機能AAAタンパク質p97の機能解析 : 各ドメインの生体内機能と生化学的機能"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T18:19:18.247028+00:00"}