@article{oai:kumadai.repo.nii.ac.jp:00024847,
 author = {小森, 宏之 and 別府, 透 and 馬場, 祥史 and 堀野, 敬 and 増田, 稔郎 and 林, 洋光 and Hayashi, Hiromitsu and 岡部, 弘尚 and 太田尾, 龍 and 渡邊, 雅之 and Takamori, Hiroshi and 高森, 啓史 and 猪山, 賢一 and 馬場, 秀夫 and 小森, 宏之 and Komori, Hiroyuki and Beppu, Toru and 馬場, 祥史 and Baba, Yoshihumi and Horino, Kei and Imsung, Choi and 増田, 稔郎 and Masuda, Toshiro and 林, 洋光 and Hayashi, Hiromitsu and Okabe, Hirohisa and Ootao, Ryuu and 渡邊, 雅之 and Watanabe, Masayuki and Takamori, Hiroshi and Iyama, Kenichi and Baba, Hideo},
 issue = {3},
 journal = {International Journal of Clinical Oncology},
 month = {Jun},
 note = {application/pdf, application/pdf, 論文(Article), Background This study was performed to clarify the influence of preoperative chemotherapy on liver function and the correlation between histological hepatic injury and the postoperative outcome in patients with colorectal liver metastases who underwent a hepatic resection. Methods Twenty-seven patients who underwent a hepatic resection for colorectal liver metastases were included. Fifteen patients with initially unresectable colorectal liver metastases who were able to undergo a tumor resection after FOLFOX (oxaliplatin plus fluorouracil and leucovorin, with a mean number of 7.7 cycles) were compared to 12 patients who underwent a hepatectomy with no preoperative chemotherapy. The postoperative mortality, morbidity, changes in liver function tests, and pathology of the resected liver were examined. Results Preoperative FOLFOX therapy was significantly associated with the macroscopic appearance of oxaliplatinassociated blue liver (p = 0.02), and a tendency toward sinusoidal dilatation (33.3% in the FOLFOX group versus 8.3% in the no-chemotherapy group, p = 0.056). Preoperative liver function tests showed that the albumin and indocyanine green retention rate at 15 min (ICG-R15) test values were significantly worse after FOLFOX therapy; however, intraoperative events, postoperative liver function test values, and morbidity rates were similar in the two groups. There was no postoperative mortality in any of the patients. Conclusions Although preoperative FOLFOX administration in patients with colorectal liver metastases caused macroscopic blue liver, microscopic sinusoidal dilatationin the liver parenchyma, and a significant decrease in liver function, there was no increase in the morbidity and mortality rates, in comparison to findings in patients without preoperative chemotherapy., http://www.springerlink.com/content/pnr82711x3652312/},
 pages = {263--270},
 title = {Histological liver injury and surgical outcome after FOLFOX followed by a hepatectomy for colorectal liver metastases in Japanese patients},
 volume = {15},
 year = {2010},
 yomi = {ハヤシ, ヒロミツ and タカモリ, ヒロシ and コモリ, ヒロユキ and ババ, ヨシフミ and マスダ, トシロウ and ハヤシ, ヒロミツ and ワタナベ, マサユキ}
}