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Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia
http://hdl.handle.net/2298/24701
http://hdl.handle.net/2298/24701695787c3-7b85-4ba6-b4b1-29a1ff3c00c1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
TDM_33_2_244-250.pdf (192.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-05-24 | |||||
| タイトル | ||||||
| タイトル | Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | imatinib, pharmacogenetics, pharmacokinetics, chronic myeloid leukemia | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Yamakawa, Yuji
× Yamakawa, Yuji× 濱田, 哲暢× Nakashima, Reiko× Yuki, Misato× Hirayama, Chie× Kawaguchi, Tatsuya× Saito, Hideyuki |
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| 別言語の著者 |
山川, 裕司
× 山川, 裕司× 濱田, 哲暢× 中島, 麗子× 結城, 美里× 平山, 知絵× 川口, 辰哉× 齋藤, 秀之 |
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| 内容記述 | ||||||
| 内容記述 | This study explored the association of 14 single nucleotide polymorphisms (SNPs) in 3 genes coding for influx transporters (SLC22A1, SLCO1B1, and SLCO1B3), 2 genes coding for efflux transporters (ABCB1 and ABCG2), and 4 genes coding for enzymes (CYP2C9, CYP2C19, CYP2D6, and CYP3A5) with the pharmacokinetics of imatinib in Japanese patients with chronic myeloid leukemia (CML). Pharmacokinetic parameters were estimated by a population pharmacokinetic analysis based on 622 plasma samples from 34 patients at steady-state. Approximately 4.6-fold variability in individual clearance was observed (range, 3.4-15.5 L/hr). The individual estimated clearance was significantly increased in patients with SLCO1B3 334GG genotype (median value ± SD, 9.5 ± 3.1 L/hr; n = 19) compared with SLCO1B3 334TT and TG genotypes (7.0 ± 3.1 L/hr; n = 15) (P = 0.019). Patients with ABCB1 3435CC genotype had significantly higher imatinib clearance (12.7 ± 3.0 L/hr; n = 7) compared with patients with ABCB1 3435CT and TT genotypes (7.9 ± 2.7 L/hr; n= 27) (P = 0.035). In conclusion, the present study suggests that SNPs of the influx transporter SLCO1B3 and the efflux transporter ABCB1 were functionally associated with individual variability of imatinib pharmacokinetics in Japanese patients with CML. |
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| 書誌情報 |
Therapeutic Drug Monitoring 巻 33, 号 2, p. 244-250, 発行年 2011-04-01 |
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| ISSN | ||||||
| 収録物識別子 | 01634356 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 21311410 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1097/FTD.0b013e31820beb02 | |||||
| 権利 | ||||||
| 権利情報 | © 2011 by Lippincott Williams & Wilkins | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 01634356 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 192204 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 499 | |||||
| 出版者 | ||||||
| 出版者 | Lippincott Williams & Wilkins | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
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| Journal Article | ||||||
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| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://journals.lww.com/drug-monitoring/pages/issuelist.aspx | |||||
