@article{oai:kumadai.repo.nii.ac.jp:00024872,
 author = {島田, 秀昭 and Shimada, Hideaki and 衞藤, 仁 and 大田黒, 弥紗 and 大坪, 路弘 and 水上, 洋介 and 井出, 剛 and 今村, 順茂 and Imamura, Yorishige and 島田, 秀昭 and Shimada, Hideaki and Eto, Masashi and Ohtaguro, Misa and Ohtsubo, Michihiro and Mizukami, Yosuke and Ide, Tsuyoshi and 今村, 順茂 and Imamura, Yorishige},
 issue = {4},
 journal = {Journal of Biochemical and Molecular Toxicology},
 month = {Jul},
 note = {application/pdf, application/pdf, 論文(Article), The inhibitory effects of flavonoids on the human cytochrome P450 1A2 (CYP1A2) were examined. Among flavonoids tested, galangin, kaempferol, chrysin, and apigenin were potent inhibitors. Although apigenin belonging to flavones and genistein belonging to isoflavones are similar in the chemical structures, the inhibitory potencies for CYP1A2 were distinguished markedly between these two flavonoids. In computer-docking simulation, apigenin interacted with the same mode of cocrystallized α-naphthoflavone in the active site of CYP1A2, and then the B ring of apigenin was placed close to the heme iron of the enzyme with a single orientation. In contrast, the docked genistein conformation showed two different binding modes, and the A ring of genistein was oriented to the heme iron of CYP1A2. Furthermore, the binding free energy of apigenin was lower than that of genistein. These results demonstrate a possible mechanism that causes the differential inhibitory potencies of apigenin and genistein for CYP1A2., http://onlinelibrary.wiley.com/doi/10.1002/jbt.20328/abstract?systemMessage=Wiley+Online+Library+will+be+disrupted+9+July+from+10-12+BST+for+monthly+maintenance},
 pages = {230--234},
 title = {Differential mechanisms for the inhibition of human cytochrome P450 1A2 by apigenin and genistein},
 volume = {24},
 year = {2010},
 yomi = {シマダ, ヒデアキ and イマムラ, ヨリシゲ and シマダ, ヒデアキ and イマムラ, ヨリシゲ}
}