@article{oai:kumadai.repo.nii.ac.jp:00024891,
 author = {梶原, 隆太郎 and Kajihara, Ryutaro and 福重, 翔太 and Fukushige, Shota and 田邊, 香野 and Tanabe, Kano and 乾, 誠司 and Inui, Seiji},
 journal = {熊本大学医学部保健学科紀要},
 month = {Mar},
 note = {Cell division relies on the activation of cyclins, which bind to cyclin-dependent kinases (CDKs) to induce cell cycle progression towards S phase and later to initiate mitosis. Since uncontrolled cyclin-dependent kinase activity is often the cause of human cancer, their function is tightly regulated by cell-cycle inhibitors such as the p21 and p27 Cip/Kip proteins. Following anti-mitogenic signals or DNA damage, p21 and p27 bind to cyclin-CDK complexes to inhibit their catalytic activity and induce cell-cycle arrest. Interestingly, recent discoveries suggest that p21 and p27 might have new activities that are unrelated to their function as CDK inhibitors. The identification of new targets of Cip/Kip proteins as well as evidence of Cip/Kip cytoplasmic relocalization have revealed unexpected functions of these proteins in the regulation of apoptosis. This article discusses recent insights into this possible additional functions of p21 and p27.},
 pages = {1--9},
 title = {CDKインヒビターによるアポトーシス制御},
 volume = {7},
 year = {2011},
 yomi = {カジハラ, リュウタロウ and フクシゲ, ショウタ and タナベ, カノ and イヌイ, セイジ}
}