{"created":"2023-06-19T09:12:58.039903+00:00","id":24891,"links":{},"metadata":{"_buckets":{"deposit":"909be195-8afd-456d-9f03-559343168fdb"},"_deposit":{"created_by":12,"id":"24891","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"24891"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024891","sets":["413:414","585:612:1262"]},"author_link":["157885","157886","157887","157888"],"item_15_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-23","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"9","bibliographicPageStart":"1","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"熊本大学医学部保健学科紀要","bibliographic_titleLang":"ja"}]}]},"item_15_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Cell division relies on the activation of cyclins, which bind to cyclin-dependent kinases (CDKs) to induce cell cycle progression towards S phase and later to initiate mitosis. Since uncontrolled cyclin-dependent kinase activity is often the cause of human cancer, their function is tightly regulated by cell-cycle inhibitors such as the p21 and p27 Cip/Kip proteins. Following anti-mitogenic signals or DNA damage, p21 and p27 bind to cyclin-CDK complexes to inhibit their catalytic activity and induce cell-cycle arrest. Interestingly, recent discoveries suggest that p21 and p27 might have new activities that are unrelated to their function as CDK inhibitors. The identification of new targets of Cip/Kip proteins as well as evidence of Cip/Kip cytoplasmic relocalization have revealed unexpected functions of these proteins in the regulation of apoptosis. This article discusses recent insights into this possible additional functions of p21 and p27.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_15_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学","subitem_publisher_language":"ja"}]},"item_15_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1880-7151","subitem_source_identifier_type":"PISSN"}]},"item_15_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12010572","subitem_source_identifier_type":"NCID"}]},"item_15_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"463.6","subitem_subject_scheme":"NDC"}]},"item_15_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"梶原, 隆太郎","creatorNameLang":"ja"},{"creatorName":"カジハラ, リュウタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Kajihara, Ryutaro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"157885","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福重, 翔太","creatorNameLang":"ja"},{"creatorName":"フクシゲ, ショウタ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukushige, Shota","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"157886","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田邊, 香野","creatorNameLang":"ja"},{"creatorName":"タナベ, カノ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanabe, Kano","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"157887","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"乾, 誠司","creatorNameLang":"ja"},{"creatorName":"イヌイ, セイジ","creatorNameLang":"ja-Kana"},{"creatorName":"Inui, Seiji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"157888","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"MH0007_001-0009.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"MH0007_001-0009.pdf","url":"https://kumadai.repo.nii.ac.jp/record/24891/files/MH0007_001-0009.pdf"},"version_id":"5afa47d2-ef9f-41ad-b617-f3c88c6aeda6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cell cycle","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cyclin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cyclin-depedent kinase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"p27","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"p21","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Apoptosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"CDKインヒビターによるアポトーシス制御","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CDKインヒビターによるアポトーシス制御","subitem_title_language":"ja"},{"subitem_title":"CDK インヒビター ニ ヨル アポトーシス セイギョ","subitem_title_language":"ja-Kana"},{"subitem_title":"Cyclin-dependent kinase inhibitors in the regulation of apoptosis","subitem_title_language":"en"}]},"item_type_id":"15","owner":"12","path":["414","1262"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-07-08"},"publish_date":"2011-07-08","publish_status":"0","recid":"24891","relation_version_is_last":true,"title":["CDKインヒビターによるアポトーシス制御"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-10-19T01:15:01.034928+00:00"}