@article{oai:kumadai.repo.nii.ac.jp:00024896,
 author = {近藤, 龍也 and 佐々木, 一成 and 足立, 博紀 and 中山, 善晴 and 羽手村, 昌宏 and 松山, 利奈 and 水流添, 覚 and 古川, 昇 and 本島, 寛之 and 森野, 沙緒里 and 山下, 康行 and 宮村, 信博 and 甲斐, 広文 and 荒木, 栄一 and Kondo, Tatsuya and 佐々木, 一成 and Sasaki, Kazunari and Adachi, Hironori and Nakayama, Yoshiharu and Hatemura, Masahiro and Matsuyama, Rina and Tsuruzoe, Kaku and Furukawa, Noboru and Motoshima, Hiroyuki and Morino-Koga, Saori and 古賀, 沙緒里 and 森野 古賀, 沙緒里 and 山下, 康行 and Yamashita, Yasuyuki and Miyamura, Nobuhiro and Kai, Hirofumi and 荒木, 栄一 and Araki, Eiichi},
 issue = {2},
 journal = {Obesity Research &Clinical Practice},
 month = {Apr},
 note = {application/pdf, 論文(Article), Objective: Obesity induces chronic inflammation, which contributes to the development and progression of insulin resistance, diabetes and atherosclerosis. 
 We have recently shown that induction of heat shock protein 72 by mild electric current and thermo (MET) treatment in mouse model of type 2 diabetes ameliorated glucose homeostasis and insulin resistance accompanied by reduced adiposity. For clinical application of MET, we confirmed its safety in healthy subjects.
Methods: MET was applied for 10 healthy Japanese male (12V, 55 pulses per second, 30 min at 42oC) twice a week for 8 weeks. Fat volume was measured by CT scan and several parameters were investigated. 
Results: MET did not induce any adverse effects nor muscle contraction/pain. There were no significant alterations in glucose homeostasis or insulin resistance. Visceral and subcutaneous fat volume showed a trend of decrease without significant difference (- 3.9% and - 4.3%, respectively), which were restored 8 weeks after withdrawal of MET. Interestingly, serum tumor necrosis factor- (TNF-:0.91 ± 0.05 v.s. 0.67 ± 0.06 pg/mL; p =0.006) and high sensitivity-C reactive protein (hs-CRP: 521.9 ± 73.9 v.s. 270.8 ± 43.7 ng/mL; p=0.023) levels , both of which are associated with chronic inflammation, were significantly decreased. 
Conclusion: MET may be beneficial for the reduction of an inflammatory response observed in diabetes and metabolic syndrome., http://www.sciencedirect.com/science/article/pii/S1871403X09000817},
 pages = {e101--e109},
 title = {Heat shock treatment with mild electrical stimulation safely reduced inflammatory markers in healthy male subjects},
 volume = {4},
 year = {2010},
 yomi = {ササキ, カズナリ and コガ, サオリ and ヤマシタ, ヤスユキ and アラキ, エイイチ}
}