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Involvement of M2-polarized macrophages in the ascites from advanced epithelial ovarian carcinoma in tumor progression via Stat3 activation
http://hdl.handle.net/2298/22264
http://hdl.handle.net/2298/22264b366e65f-0379-4b6f-b36e-4d0b0c0e2422
| 名前 / ファイル | ライセンス | アクション |
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CS_101_10_Figures.pdf (637.3 kB)
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CS_101_10_2128-2136.pdf (212.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-11-17 | |||||
| タイトル | ||||||
| タイトル | Involvement of M2-polarized macrophages in the ascites from advanced epithelial ovarian carcinoma in tumor progression via Stat3 activation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | epithelial ovarian cancer, ascites macrophages, cancer metastasis | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Takaishi, Kiyomi
× Takaishi, Kiyomi× Komohara, Yoshihiro× 田代, 浩徳× Ohtake, Hideyuki× Nakagawa, Takenobu× Katabuchi, Hidetaka× 竹屋, 元裕 |
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| 別言語の著者 |
高石, 清美
× 高石, 清美× 菰原, 義弘× 田代, 浩徳× 大竹, 秀幸× 中川, 雄伸× 片渕, 秀隆× 竹屋, 元裕 |
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| 内容記述 | ||||||
| 内容記述 | Ascites macrophages in advanced epithelial ovarian cancer (AdEOC) are involved in cancer metastasis and progression by modifying the tumor microenvironment. However, the precise mechanisms of cell-to-cell interaction between macrophages and tumor cells are still unclear. This study focused on the activation of signal transducer and activator of transcription 3 (Stat3) which is a critical signal transduction molecule at a point of convergence for numerous oncogenic signaling pathways as well as controlling the M2-poralization of macrophages. AdEOC ascites, in which high concentration of interleukin (IL)-6, IL-10, growth-related oncogene-alpha and vascular endothelial growth factor were detected, stimulated the proliferation of SKOV3 cells, a human ovarian cancer cell line. The simultaneous blocking of IL-6 and IL-10 by neutralizing antibodies suppressed ascites-induced tumor cell proliferation. Stat3 activation in SKOV3 cells was induced by co-culture with macrophages especially with macrophage colony stimulating factor-primed M2 macrophages but lesser extent with granulocyte-macrophage colony stimulating factor-primed immature macrophages. Cyclin-D1 expression in SKOV3 cells was also significantly induced by co-culture with macrophages. Blocking of Stat3 in macrophages by small interfering RNA inhibited the production of IL-6 and IL-10 by macrophages, and suppressed Stat3 activation and cyclin-D1 induction in co-cultured SKOV3 cells. Stat3 activation in SKOV3 cells was abrogated by simultaneous neutralization of IL-6 and IL-10. These results indicate that Stat3 activation by IL-6 and IL-10 plays an important role in cell-to-cell interaction between tumor cells and macrophages in the ascites of AdEOC. | |||||
| 書誌情報 |
Cancer Science 巻 101, 号 10, p. 2128-2136, 発行年 2010-10 |
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| ISSN | ||||||
| 収録物識別子 | 13479032 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11808050 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 20860602 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1111/j.1349-7006.2010.01652.x | |||||
| 権利 | ||||||
| 権利情報 | © 2010 Japanese Cancer Association. | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 13479032 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 212073 bytes | ||||||
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| 637335 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491.6 | |||||
| 出版者 | ||||||
| 出版者 | Japanese Cancer Association | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
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| 雑誌掲載論文 | ||||||
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| Journal Article | ||||||
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| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.2010.01652.x/abstract;jsessionid=D72C36F88CD7C09198DC3D62C24CFEA9.d01t04 | |||||
