{"created":"2023-06-19T09:12:58.407266+00:00","id":24899,"links":{},"metadata":{"_buckets":{"deposit":"9d4d1bcb-c542-4eb7-bed6-c8fab523da18"},"_deposit":{"created_by":1,"id":"24899","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"24899"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024899","sets":["413:443"]},"author_link":["112312","112302","112303","112301","112315","112314","112318","165839","112298","112317","112316","112313","112299"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"2136","bibliographicPageStart":"2128","bibliographicVolumeNumber":"101","bibliographic_titles":[{"bibliographic_title":"Cancer Science"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高石, 清美"}],"nameIdentifiers":[{"nameIdentifier":"112312","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菰原, 義弘"}],"nameIdentifiers":[{"nameIdentifier":"112313","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"田代, 浩徳","creatorNameLang":"ja"},{"creatorName":"タシロ, ヒロノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Tashiro, Hironori","creatorNameLang":"en"}],"familyNames":[{"familyName":"田代","familyNameLang":"ja"},{"familyName":"タシロ","familyNameLang":"ja-Kana"},{"familyName":"Tashiro","familyNameLang":"en"}],"givenNames":[{"givenName":"浩徳","givenNameLang":"ja"},{"givenName":"ヒロノリ","givenNameLang":"ja-Kana"},{"givenName":"Hironori","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"112314","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大竹, 秀幸"}],"nameIdentifiers":[{"nameIdentifier":"112315","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中川, 雄伸"}],"nameIdentifiers":[{"nameIdentifier":"112316","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"片渕, 秀隆"}],"nameIdentifiers":[{"nameIdentifier":"112317","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"竹屋, 元裕"}],"nameIdentifiers":[{"nameIdentifier":"112318","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Ascites macrophages in advanced epithelial ovarian cancer (AdEOC) are involved in cancer metastasis and progression by modifying the tumor microenvironment. However, the precise mechanisms of cell-to-cell interaction between macrophages and tumor cells are still unclear. This study focused on the activation of signal transducer and activator of transcription 3 (Stat3) which is a critical signal transduction molecule at a point of convergence for numerous oncogenic signaling pathways as well as controlling the M2-poralization of macrophages. AdEOC ascites, in which high concentration of interleukin (IL)-6, IL-10, growth-related oncogene-alpha and vascular endothelial growth factor were detected, stimulated the proliferation of SKOV3 cells, a human ovarian cancer cell line. The simultaneous blocking of IL-6 and IL-10 by neutralizing antibodies suppressed ascites-induced tumor cell proliferation. Stat3 activation in SKOV3 cells was induced by co-culture with macrophages especially with macrophage colony stimulating factor-primed M2 macrophages but lesser extent with granulocyte-macrophage colony stimulating factor-primed immature macrophages. Cyclin-D1 expression in SKOV3 cells was also significantly induced by co-culture with macrophages. Blocking of Stat3 in macrophages by small interfering RNA inhibited the production of IL-6 and IL-10 by macrophages, and suppressed Stat3 activation and cyclin-D1 induction in co-cultured SKOV3 cells. Stat3 activation in SKOV3 cells was abrogated by simultaneous neutralization of IL-6 and IL-10. These results indicate that Stat3 activation by IL-6 and IL-10 plays an important role in cell-to-cell interaction between tumor cells and macrophages in the ascites of AdEOC.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.2010.01652.x/abstract;jsessionid=D72C36F88CD7C09198DC3D62C24CFEA9.d01t04","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Cancer 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