@article{oai:kumadai.repo.nii.ac.jp:00024914,
 author = {井田, 智 and 大村谷, 昌樹 and 廣田, 昌彦 and 尾崎, 宣之 and 平松, さやか and 上原, 仁 and Takamori, Hiroshi and 高森, 啓史 and 荒木, 喜美 and 馬場, 秀夫 and 山村, 研一 and 井田, 智 and Ida, Satoshi and Ohmuraya, Masaki and Hirota, Masahiko and Ozaki, Nobuyuki and Hiramatsu, Sayaka and Uehara, Hitoshi and Takamori, Hiroshi and 荒木, 喜美 and Araki, Kimi and Baba, Hideo and Yamamura, Ken-ichi},
 issue = {4},
 journal = {Experimental Animals},
 month = {Jul},
 note = {application/pdf, 論文(Article), Although chronic pancreatitis is a risk factor for pancreatic ductal adenocarcinoma (PDA), the relationship between chronic pancreatitis and PDA remains obscure. A critical obstacle to understanding the role of chronic pancreatitis is the lack of animal models. To develop one such model, mice were fed long-term with a choline deficient ethionine-supplemented (CDE) diet. Histological evaluation revealed that chronic pancreatitis, characterized by acinar atrophy, fibrosis and well-developed tubular complexes (TCs), was observed after 24 weeks of CDE diet treatment. Furthermore, expression of epidermal growth factor receptor (EGFR) and its ligands; serine protease inhibitor Kazal type 3 (Spink3) and transforming growth factor α (TGF α) and activation of K-Ras (GTP-Ras formation), which are frequently observed in human PDA, were indeed observed in parallel with TCs formation. Neoplastic lesions were not found after 54 weeks of treatment, suggesting that a continuation of CDE diet or another insult is required for the development of PDA., http://www.jstage.jst.go.jp/article/expanim/59/4/59_421/_article/-char/ja/},
 pages = {421--429},
 title = {Chronic Pancreatitis in Mice by Treatment with Choline-Deficient Ethionine-Supplemented Diet},
 volume = {59},
 year = {2010},
 yomi = {タカモリ, ヒロシ and イダ, サトシ and アラキ, キミ}
}