{"created":"2023-06-19T09:13:07.963312+00:00","id":25095,"links":{},"metadata":{"_buckets":{"deposit":"b778e0ef-1a9b-4f70-9240-9cd5b72c4ea4"},"_deposit":{"created_by":1,"id":"25095","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"25095"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00025095","sets":["413:443"]},"author_link":["113836","132733","113831","113848","113850","113851","113834","113846","113847","113845","113837","113849","92665"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"PLoS ONE"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐藤, 義則"}],"nameIdentifiers":[{"nameIdentifier":"113845","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高田, 比呂志"}],"nameIdentifiers":[{"nameIdentifier":"113846","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"小林, 直樹","creatorNameLang":"ja"},{"creatorName":"コバヤシ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kobayashi, Naoki","creatorNameLang":"en"}],"familyNames":[{"familyName":"小林","familyNameLang":"ja"},{"familyName":"コバヤシ","familyNameLang":"ja-Kana"},{"familyName":"Kobayashi","familyNameLang":"en"}],"givenNames":[{"givenName":"直樹","givenNameLang":"ja"},{"givenName":"ナオキ","givenNameLang":"ja-Kana"},{"givenName":"Naoki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"113847","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"永田, 紗矢香"}],"nameIdentifiers":[{"nameIdentifier":"113848","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中潟, 直己"}],"nameIdentifiers":[{"nameIdentifier":"113849","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上野, 貴将"}],"nameIdentifiers":[{"nameIdentifier":"113850","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"滝口, 雅文"}],"nameIdentifiers":[{"nameIdentifier":"113851","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Humanized mice, which are generated by transplanting human CD34+ hematopoietic stem cells into immunodeficient mice, are expected to be useful for the research on human immune responses. It is reported that antigen-specific T cell responses occur in immunodeficient mice transplanted with both human fetal thymus/liver tissues and CD34+ fetal cells, but it remains unclear whether antigen-specific T cell responses occur in those transplanted with only human CD34+ hematopoietic stem cells (HSCs). Here we investigated the differentiation and function of human CD8+ T cells reconstituted in NOD/SCID/Jak3-/- mice transplanted with human CD34+ HSCs (hNOK mice). Multicolor flow cytometric analysis demonstrated that human CD8+T cells generated from the CD34+ HSCs comprised only 3 subtypes, i.e., CD27highCD28+CD45RA++CCR7+, CD27+CD28++CD45R-A2CCR7+, and CD27 +CD28+CD45RA-CCR7- and had 3 phenotypes for 3 lytic molecules, i.e., perforin(Per)-granzymeA(GraA)-granzymeB(GraB)-, Per-GraA+GraB-, and PerlowGraA+GraB+. These CD8+ T cells failed to produce IFN-γ and to proliferate after stimulation with alloantigens. These results indicate that the antigen-specific T cell response cannot be elicited in mice transplanted with only human CD34+ HSCs, because the T cells fail to develop normally in such mice.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0013109@@@20957041","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of 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ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Takata, Hiroshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"高田","familyNameLang":"ja"},{"familyName":"タカタ","familyNameLang":"ja-Kana"},{"familyName":"Takata","familyNameLang":"en"}],"givenNames":[{"givenName":"比呂志","givenNameLang":"ja"},{"givenName":"ヒロシ","givenNameLang":"ja-Kana"},{"givenName":"Hiroshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92665","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"小林, 直樹","creatorNameLang":"ja"},{"creatorName":"コバヤシ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kobayashi, Naoki","creatorNameLang":"en"}],"familyNames":[{"familyName":"小林","familyNameLang":"ja"},{"familyName":"コバヤシ","familyNameLang":"ja-Kana"},{"familyName":"Kobayashi","familyNameLang":"en"}],"givenNames":[{"givenName":"直樹","givenNameLang":"ja"},{"givenName":"ナオキ","givenNameLang":"ja-Kana"},{"givenName":"Naoki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"113847","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagata, Sayaka"}],"nameIdentifiers":[{"nameIdentifier":"113834","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"中潟, 直己","creatorNameLang":"ja"},{"creatorName":"ナカガタ, ナオミ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakagata, Naomi","creatorNameLang":"en"}],"familyNames":[{"familyName":"中潟","familyNameLang":"ja"},{"familyName":"ナカガタ","familyNameLang":"ja-Kana"},{"familyName":"Nakagata","familyNameLang":"en"}],"givenNames":[{"givenName":"直己","givenNameLang":"ja"},{"givenName":"ナオミ","givenNameLang":"ja-Kana"},{"givenName":"Naomi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"132733","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ueno, Takamasa"}],"nameIdentifiers":[{"nameIdentifier":"113836","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takiguchi, Masafumi"}],"nameIdentifiers":[{"nameIdentifier":"113837","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"journal.pone.0013109.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"journal.pone.0013109.pdf","url":"https://kumadai.repo.nii.ac.jp/record/25095/files/journal.pone.0013109.pdf"},"version_id":"695ec40c-ad1d-4a2c-a0f1-7d33ddd59c7c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Failure of Effector Function of Human CD8+ T Cells in NOD/SCID/JAK3−/− Immunodeficient Mice Transplanted with Human CD34+ Hematopoietic Stem Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Failure of Effector Function of Human CD8+ T Cells in NOD/SCID/JAK3−/− Immunodeficient Mice Transplanted with Human CD34+ Hematopoietic Stem Cells"}]},"item_type_id":"16","owner":"1","path":["443"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-08-08"},"publish_date":"2011-08-08","publish_status":"0","recid":"25095","relation_version_is_last":true,"title":["Failure of Effector Function of Human CD8+ T Cells in NOD/SCID/JAK3−/− Immunodeficient Mice Transplanted with Human CD34+ Hematopoietic Stem Cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-09-13T06:00:05.432848+00:00"}