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The Skt gene, required for anorectal development, is a candidate for a molecular marker of the cloacal plate
http://hdl.handle.net/2298/24427
http://hdl.handle.net/2298/24427f437d21c-d84e-4711-8e52-79cf9d14b235
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Fig2.pdf (116.1 kB)
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Fig1.pdf (105.8 kB)
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PSI27-3-269-273.pdf (148.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-05-08 | |||||
| タイトル | ||||||
| タイトル | The Skt gene, required for anorectal development, is a candidate for a molecular marker of the cloacal plate | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | ARMs, Cloacal plate, Danforth's short tail mice, Skt, Anorectal development | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Suda, Hiroko
× Suda, Hiroko× Lee, Kwang-Jong× Semba, Kei× Kyushima, Fumie× Ando, Takashi× 荒木, 正健× 荒木, 喜美× Inomata, Yukihiro× Yamamura, Ken-ichi |
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| 別言語の著者 |
須田, 博子
× 須田, 博子× 仙波, 圭× 久嶋, 史枝× 安藤, 卓× 荒木, 正健× 荒木, 喜美× 猪股, 裕紀洋× 山村, 研一 |
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| 内容記述 | ||||||
| 内容記述 | Background and aims: It has been reported that a dorsal cloacal plate defect is associated with anorectal malformations (ARMs); however, there has been very little information reported about the developmental mechanisms involved with cloacal plate formation. Danforth's short tail (Sd) mutant mice show ARMs. In our previous study, the co-presence of Skt Gt mutation, in which Skt gene is disrupted by the gene-trap vector (p-U8), increased the incidence of ARMs in Sd mutant to 100%. Our aims in this study are determining the Skt expression around the cloaca during the anorectal development and demonstrating the role of Skt gene in ARMs. Methods: Embryos, normal controls [+Skt Gt /+Skt Gt ] and ARMs models [Sd Skt Gt /+Skt Gt ], from embryonic day (E) 9.5 to E12.5, were evaluated with X-gal staining. Results: In control embryos, Skt expression was detected both in the endoderm and ectoderm of the cloacal plate from E9.5 onward. At E12.5, Skt expression was also detected in the mesenchyme neighboring the dorsal cloacal plates. In [Sd Skt Gt /+Skt Gt ] mutant embryos, the cloacal plates failed to extend proximodistally and, consequently, the dorsal part of cloacal plate was defective at E11.5. Skt expressing cells were detected in the shortened cloacal plate and in the thickened mesenchyme dorsal to it. Conclusions: We showed the spatial and temporal expression of Skt gene in the cloacal plate formation. This gene could be a marker for the cloacal plate during the anorectal development. Furthermore, Skt was considered to be associated with the embryogenesis of ARMs. | |||||
| 書誌情報 |
Pediatric Surgery International 巻 27, 号 3, p. 269-273, 発行年 2011-03 |
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| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 21069351 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1007/s00383-010-2785-0 | |||||
| 権利 | ||||||
| 権利情報 | © 2011 Springer-Verlag. | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 01790358 | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 内容記述タイプ | Other | |||||
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| 内容記述タイプ | Other | |||||
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| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491.2 | |||||
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| 出版者 | Springer-Verlag. | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
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| 雑誌掲載論文 | ||||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.springerlink.com/content/j554704m1qvq2u9v/ | |||||
