@article{oai:kumadai.repo.nii.ac.jp:00025109,
 author = {楠本, 将裕 and 鴨林, 宏樹 and Kamobayashi, Hiroki and 佐藤, 大介 and 小森, めぐみ and 脇田, 紋佳 and 吉村, 美里 and 濱田, 哲暢 and 江​田, ​幸​政 and 冨田, 公夫 and 齋藤, 秀之 and Kusumoto, Masahiro and 鴨林, 宏樹 and Kamobayashi, Hiroki and Sato, Daisuke and Komori, Megumi and Wakida, Ayaka and Yoshimura, Misato and 濱田, 哲暢 and Hamada, Akinobu and Kohda, Yukimasa and Tomita, Kimio and Saito, Hideyuki},
 issue = {6},
 journal = {Clinical and Experimental Nephrology},
 month = {Dec},
 note = {application/pdf, 論文(Article), Background:Polyphenols such as quercetin have been reported to prevent cisplatin-induced acute kidney injury (AKI). Indoxyl sulfate (IS), a uremic toxin generated in the liver, is increased in cisplatin AKI. The present study examined the effect of phytochemical polyphenols on serum and renal accumulations of IS in association with cisplatin AKI. 
Methods:Sprague-Dawley rats were treated with cisplatin (10 mg/kg body weight) by intraperitoneal injection. Polyphenols were orally administered at -24, -1, 24 and 48 hr before or after cisplatin injection. Serum levels of IS, cisplatin, serum creatinine (SCr), blood urea nitrogen (BUN) and electrolytes were measured. By using in vitro assay system with rat liver S9 fraction, the inhibitory potencies of several compounds on IS production were determined. 
Results:Injection of cisplatin in rats markedly elevated the SCr and BUN levles, which were accompanied by tubular injuries and the expression of kidney injury molecule-1 (Kim-1). By contrast, quercetin significantly suppressed the SCr and BUN levels in the cisplatin-treated rats and protected them against renal injury with the decreased expression of Kim-1. Quercetin had no effect on serum and renal levels of cisplatin. In addition, quercetin had no effect on cisplatin-induced renal accumulation of malondialdehyde. IS concentrations in serum, kidney, liver, intestine and lung were markedly elevated by cisplatin treatment, whereas quercetin suppressed the serum and tissue IS levels. An in vitro kinetic assay revealed that quercetin displayed a potent inhibitory effect on hepatic production of IS.
Conclusion:Inhibition of IS accumulation by oral administration of quercetin alleviates cisplatin-induced AKI., http://www.springerlink.com/content/051w24k21l103266/},
 pages = {820--830},
 title = {Alleviation of cisplatin-induced acute kidney injury using phytochemical polyphenols is accompanied by reduced accumulation of indoxyl sulfate in rats},
 volume = {15},
 year = {2011},
 yomi = {カモバヤシ, ヒロキ and カモバヤシ, ヒロキ and ハマダ, アキノブ}
}