{"created":"2023-06-19T09:13:17.474991+00:00","id":25300,"links":{},"metadata":{"_buckets":{"deposit":"6a901711-8fb9-4b1a-9bc5-c78c26e67c40"},"_deposit":{"created_by":1,"id":"25300","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"25300"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00025300","sets":["343:347:348:349"]},"author_link":["115264","115266","115265"],"item_14_alternative_title_22":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"免疫抑制分子TRAILによる自己免疫疾患の制御機構に関する研究"}]},"item_14_alternative_title_23":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"メンエキ セイギョ ブンシ TRAIL ニ ヨル ジコ メンエキ シッカン ノ セイギョ キコウ ニ カンスル ケンキュウ"}]},"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-25","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_14_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ikeda, Tokunori"}],"nameIdentifiers":[{"nameIdentifier":"115266","nameIdentifierScheme":"WEKO"}]}]},"item_14_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_14_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"学位論文(Thesis)","subitem_description_type":"Other"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is known to play a pivotal role in the inhibition of autoimmune disease. We previously reported a disease-preventive effect of embryonic stem cell-derived dendritic cells (ES-DC) genetically engineered to express TRAIL along with a myelin antigen, MOG, on experimental autoimmune encephalomyelitis (EAE), and also suggested that CD4+CD25+ regulatory T (Treg) cells were involved in mediating this preventive effect. In the current study, we investigated the effect of TRAIL on Treg cells as well as conventional T cells, using TRAIL-deficient mice. Upon induction of EAE, TRAIL-deficient mice showed more severe clinical symptoms, a higher frequency of IFN-γ-producing CD4+ T (Th1) cells, and a lower frequency of CD4+Foxp3+ Treg cells than wild type mice. In vitro, conventional T cells stimulated by bone marrow-derived DC (BM-DC) from TRAIL-deficient mice showed a higher magnitude of proliferation than those stimulated by BM-DC from wild type mice. In contrast, TRAIL expressed on the stimulator BM-DC enhanced the proliferative response of CD4+CD25+ Treg cells in the culture. The functional TRAIL-receptor, mDR5, was expressed in both conventional T cells and Treg cells upon stimulation. On the other hand, the decoy receptor, mDc-TRAIL-R1 was slightly expressed only on CD4+CD25+ Treg cells. Therefore, the distinct effects of TRAIL may be due to differences in the mDc-TRAIL-R1-expreesion or the signaling pathways down-stream of mDR5 between the two T cell subsets. Our data suggests that TRAIL suppresses autoimmunity by two mechanisms; one is the inhibition of Th1 cells and the other is the promotion of Treg cells.","subitem_description_type":"Other"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"1147925 bytes"}]},"item_14_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"博士論文"}]},"item_14_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Thesis or Dissertation"}]},"item_14_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_14_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"03"}]},"item_14_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_value":"熊本大学大学院医学教育部　臨床医科学専攻"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_value":"甲博医第1771号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"池田, 徳典"}],"nameIdentifiers":[{"nameIdentifier":"115264","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"22-1771.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22-1771.pdf","url":"https://kumadai.repo.nii.ac.jp/record/25300/files/22-1771.pdf"},"version_id":"7ad2692a-80c7-4be6-a11b-603e8c6d596b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"The immunoregulatory effect of tumor necrosis factor-related apoptosis inducing ligand (TRAIL)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The immunoregulatory effect of tumor necrosis factor-related apoptosis inducing ligand (TRAIL)"}]},"item_type_id":"14","owner":"1","path":["349"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-10-03"},"publish_date":"2011-10-03","publish_status":"0","recid":"25300","relation_version_is_last":true,"title":["The immunoregulatory effect of tumor necrosis factor-related apoptosis inducing ligand (TRAIL)"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T18:13:09.014100+00:00"}