{"created":"2023-06-19T09:13:18.446206+00:00","id":25318,"links":{},"metadata":{"_buckets":{"deposit":"ffea1d63-f2d3-49f7-b10f-6e73695d9bc5"},"_deposit":{"created_by":127,"id":"25318","owners":[127],"pid":{"revision_id":0,"type":"depid","value":"25318"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00025318","sets":["343:347:348:349"]},"author_link":[],"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-25","bibliographicIssueDateType":"Issued"}}]},"item_14_date_granted_74":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2011-03-25"}]},"item_14_degree_grantor_72":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"熊本大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_14_degree_name_71":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"mTORはPI3K/Akt経路の下流に位置し、cell growthの制御やアポトーシス抑制に関与する。各種の癌細胞においてmTORは高発現し、癌細胞の浸潤・転移に関与することが報告されている。また、mTOR阻害剤は様々な癌腫に対して抗腫瘍効果を示し、臨床試験も多数行われている。しかし、食道扁平上皮癌におけるmTORの重要性は明らかになっていない。食道扁平上皮癌は悪性度が高く、手術と科学放射線療法による治療成績は未だ不十分である。我々は更なる治療成績向上を目指し、食道扁平上皮癌におけるmTOR発現の意義を解明し、mTORが分子標的治療のtargetとなりうるかを検討することとした。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_14_dissertation_number_75":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1777号"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学","subitem_publisher_language":"ja"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"熊本大学大学院医学教育部　臨床医科学専攻"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲博医第1777号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平島, 浩太郎","creatorNameLang":"ja"},{"creatorName":"ヒラシマ, コウタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Hirashima, Kotaro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"22-1777.pdf","filesize":[{"value":"3.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22-1777.pdf","url":"https://kumadai.repo.nii.ac.jp/record/25318/files/22-1777.pdf"},"version_id":"726b2010-3edd-4883-a2d9-2867428754c2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"食道扁平上皮癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"mTOR","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"食道扁平上皮癌におけるmTOR発現の意義と分子標的治療のターゲットとしての可能性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"食道扁平上皮癌におけるmTOR発現の意義と分子標的治療のターゲットとしての可能性","subitem_title_language":"ja"},{"subitem_title":"ショクドウ ヘンペイ ジョウヒ ガン ニ オケル mTOR ハツゲン ノ イギ ト ブンシ ヒョウテキ チリョウ ノ ターゲット ト シテ ノ カノウセイ","subitem_title_language":"ja-Kana"},{"subitem_title":"The potential of mTOR as a therapeutic target of esophageal squamous cell carcinoma","subitem_title_language":"en"}]},"item_type_id":"14","owner":"127","path":["349"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-10-03"},"publish_date":"2011-10-03","publish_status":"0","recid":"25318","relation_version_is_last":true,"title":["食道扁平上皮癌におけるmTOR発現の意義と分子標的治療のターゲットとしての可能性"],"weko_creator_id":"127","weko_shared_id":-1},"updated":"2026-01-08T06:25:26.603891+00:00"}