{"created":"2023-06-19T09:13:19.053498+00:00","id":25330,"links":{},"metadata":{"_buckets":{"deposit":"75866871-a1f7-4ac2-8b18-cd648264e7f1"},"_deposit":{"created_by":1,"id":"25330","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"25330"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00025330","sets":["343:347:348:497"]},"author_link":["115360","110662"],"item_14_alternative_title_22":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"中枢神経系におけるTsukushi(TSK)分子の機能解析"}]},"item_14_alternative_title_23":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"チュウスウ シンケイ ケイ ニ オケル Tsukushi TSK ブンシ ノ キノウ カイセキ"}]},"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-25","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_14_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"伊藤, 綾子","creatorNameLang":"ja"},{"creatorName":"イトウ, アヤコ","creatorNameLang":"ja-Kana"},{"creatorName":"Ito, Ayako","creatorNameLang":"en"}],"familyNames":[{"familyName":"伊藤","familyNameLang":"ja"},{"familyName":"イトウ","familyNameLang":"ja-Kana"},{"familyName":"Ito","familyNameLang":"en"}],"givenNames":[{"givenName":"綾子","givenNameLang":"ja"},{"givenName":"アヤコ","givenNameLang":"ja-Kana"},{"givenName":"Ayako","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"110662","nameIdentifierScheme":"WEKO"}]}]},"item_14_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_14_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"学位論文(Thesis)","subitem_description_type":"Other"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"In this study, I investigated the TSK expression pattern in the vertebrate (chick and mouse) retina and the mouse brain. I find that TSK is expressed in the CMZ in the chick and the CB and the SVZin the mouse eye and brain, where neuronal stem/progenitor cells proliferation and differentiation are controlled by Wnt signaling. These results indicate that TSK is an important component of the stem/progenitor cells niche in the adult mammalian CB, controlling stem/progenitor cells proliferation by modulatingWnt signaling.\nIn adult mammalian brain, stem/progenitor cellsare located in the SVZ and the SGZ. TSK is strongly expressed in the SVZ and the SGZfrom neonate to the adult stages. Neuralcell types are well studied in the SVZ. To investigate which cell express TSK, I performed immunohistchemical detection and find the TSK expression in asingle layer of ependymal cells lining the ventricular cavity. Cell proliferation in the SVZ of TSK-/- brain is increased comparing to the control mouse. From the eye and the brain data, I propose that TSKregulatesthe stem/progenitor cells proliferation by modulating the pivotal signaling at the extracellular region.","subitem_description_type":"Other"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"3349322 bytes"}]},"item_14_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"博士論文"}]},"item_14_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Thesis or Dissertation"}]},"item_14_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_14_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"03"}]},"item_14_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_value":"熊本大学大学院医学教育部　生体医科学専攻"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_value":"甲博生命第13号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊藤, 綾子"}],"nameIdentifiers":[{"nameIdentifier":"115360","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"51-0013pdf.pdf","filesize":[{"value":"3.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"51-0013pdf.pdf","url":"https://kumadai.repo.nii.ac.jp/record/25330/files/51-0013pdf.pdf"},"version_id":"4418b409-f934-49dd-b80f-6daa64653bbc"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Analysis of Tsukushi (TSK) function in the central nervous system","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Analysis of Tsukushi (TSK) function in the central nervous system"}]},"item_type_id":"14","owner":"1","path":["497"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-10-05"},"publish_date":"2011-10-05","publish_status":"0","recid":"25330","relation_version_is_last":true,"title":["Analysis of Tsukushi (TSK) function in the central nervous system"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-09-26T01:40:21.325194+00:00"}