{"created":"2023-06-19T09:13:19.328620+00:00","id":25336,"links":{},"metadata":{"_buckets":{"deposit":"d96c6e25-c348-4c8a-a493-e3e041156115"},"_deposit":{"created_by":127,"id":"25336","owners":[127],"pid":{"revision_id":0,"type":"depid","value":"25336"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00025336","sets":["343:347:348:349"]},"author_link":[],"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-25","bibliographicIssueDateType":"Issued"}}]},"item_14_date_granted_74":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2011-03-25"}]},"item_14_degree_grantor_72":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"熊本大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_14_degree_name_71":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"肝臓は再生能力の高い臓器である。しかし、成体で観察される肝臓再生は、肝臓前駆細胞によるものではなく、肝細胞の増殖が制限された条件下で肝臓に障害を起こすと、門脈付近に肝細胞と胆管細胞に分化する能力（ニ分化能）を持つ前駆細胞（oval細胞）が出現し、これらの細胞は、肝臓を修復し、恒常性を担うものと考えられている。しかし、成体肝臓における前駆細胞の役割や起源については不明な点が多く、解析が進んでいない。一つの原因として、CreER^T2/loxPなどの遺伝子改変マウスを用いた細胞系譜解析を行える有用なマーカー遺伝子が少ないことがあげられる。私は、このような実験系に使用可能なマーカーの探索を行うことをめざした。当研究室では、すでにEpiplakin1(Eppk1)を膵臓の前駆細胞マーカーと同定していた。私はEppk1が成体において肝臓前駆細胞マーカーとして有用であるかを評価した。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_14_dissertation_number_75":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1788号"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学","subitem_publisher_language":"ja"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"熊本大学大学院医学教育部　生体医科学専攻"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲博医第1788号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松尾, 顕","creatorNameLang":"ja"},{"creatorName":"マツオ, アキラ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuo, Akira","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"22-1788.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22-1788.pdf","url":"https://kumadai.repo.nii.ac.jp/record/25336/files/22-1788.pdf"},"version_id":"73af808a-c0a7-4ad0-b9fa-ff98f8d6c7ff"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肝臓再生","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"成体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Eppk1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"成体における新規な肝臓前駆細胞マーカー遺伝子Epiplakin1の同定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"成体における新規な肝臓前駆細胞マーカー遺伝子Epiplakin1の同定","subitem_title_language":"ja"},{"subitem_title":"セイタイ ニ オケル シンキ ナ カンゾウ ゼンク サイボウ マーカー イデンシ Eptplakin 1 ノ ドウテイ","subitem_title_language":"ja-Kana"},{"subitem_title":"Identification of Epiplakin1 as a novel adult hepatic progenitor marker gene","subitem_title_language":"en"}]},"item_type_id":"14","owner":"127","path":["349"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-12-05"},"publish_date":"2011-12-05","publish_status":"0","recid":"25336","relation_version_is_last":true,"title":["成体における新規な肝臓前駆細胞マーカー遺伝子Epiplakin1の同定"],"weko_creator_id":"127","weko_shared_id":-1},"updated":"2026-01-08T06:26:00.318907+00:00"}