{"created":"2023-06-19T09:13:19.647019+00:00","id":25343,"links":{},"metadata":{"_buckets":{"deposit":"e7dbdffc-3b17-4584-8966-ea6c5f0524f5"},"_deposit":{"created_by":127,"id":"25343","owners":[127],"pid":{"revision_id":0,"type":"depid","value":"25343"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00025343","sets":["343:347:348:349"]},"author_link":[],"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-25","bibliographicIssueDateType":"Issued"}}]},"item_14_date_granted_74":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2011-03-25"}]},"item_14_degree_grantor_72":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"熊本大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_14_degree_name_71":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"HIV-1感染症のコントロールにおいて、ワクチンの重要性は論を待たない。しかし、有効なワクチンは未だ出来ていない。細胞傷害性T細胞(Cytotoxic T lymphocytes; CTL)は、ヒト免疫不全ウイルス(Human immunodeficiency virus type 1; HIV-1)感染細胞の除去および抑制に重要な役割を果たしていることが知られている。ワクチン開発において、それぞれのHLA拘束性のimmunodominant epitopeを明らかにしていくことが重要である。HLA-B*40:01とHLA-B*40:02はそれぞれ日本人の10.8%、16.6%が保有していると報告されている頻度の高いHLA遺伝子型である。本研究は、これらのHLAに拘束性のHIV-1特異的CTLエピトープを同定することによって、HIV-1感染症の病態とそれに対する細胞性免疫メカニズムの解明や治療への応用への一助となることを目的とした。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_14_dissertation_number_75":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1796号"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学","subitem_publisher_language":"ja"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲博医第1796号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡邉, 珠代","creatorNameLang":"ja"},{"creatorName":"ワタナベ, タマヨ","creatorNameLang":"ja-Kana"},{"creatorName":"Watanabe, Tamayo","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"22-1796.pdf","filesize":[{"value":"988.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22-1796.pdf","url":"https://kumadai.repo.nii.ac.jp/record/25343/files/22-1796.pdf"},"version_id":"435afc1d-fa81-4e3e-927d-a551774a496f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HIV","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HLA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"抗原","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"HLA-B*40:01抗原、HLA-B*40:02抗原に拘束されるHIV-1特異的CD8+ T細胞の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HLA-B*40:01抗原、HLA-B*40:02抗原に拘束されるHIV-1特異的CD8+ T細胞の解析","subitem_title_language":"ja"},{"subitem_title":"HLA B* 40 01 コウゲン HLA B* 40 02 コウゲン ニ コウソク サレル HIV 1 トクイテキ CD8+ T サイボウ ノ カイセキ","subitem_title_language":"ja-Kana"},{"subitem_title":"Analysis of HIV-1-specific cytotoxic CD8+ T lymphocyte restricted by HLA-B* 40:01 and HLA-B* 40:02","subitem_title_language":"en"}]},"item_type_id":"14","owner":"127","path":["349"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-10-05"},"publish_date":"2011-10-05","publish_status":"0","recid":"25343","relation_version_is_last":true,"title":["HLA-B*40:01抗原、HLA-B*40:02抗原に拘束されるHIV-1特異的CD8+ T細胞の解析"],"weko_creator_id":"127","weko_shared_id":-1},"updated":"2026-01-08T06:26:25.348687+00:00"}