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CTL)は、ヒト免疫不全ウイルス(Human immunodeficiency virus type 1; HIV-1)感染細胞の除去および抑制に重要な役割を果たしていることが知られている。ワクチン開発において、それぞれのHLA拘束性のimmunodominant epitopeを明らかにしていくことが重要である。HLA-B*40:01とHLA-B*40:02はそれぞれ日本人の10.8%、16.6%が保有していると報告されている頻度の高いHLA遺伝子型である。本研究は、これらのHLAに拘束性のHIV-1特異的CTLエピトープを同定することによって、HIV-1感染症の病態とそれに対する細胞性免疫メカニズムの解明や治療への応用への一助となることを目的とした。","subitem_description_type":"Other"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"988265 bytes"}]},"item_14_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"博士論文"}]},"item_14_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Thesis or Dissertation"}]},"item_14_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_14_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"03"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_value":"甲博医第1796号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"渡邉, 珠代","creatorNameLang":"ja"},{"creatorName":"ワタナベ, タマヨ","creatorNameLang":"ja-Kana"},{"creatorName":"Watanabe, Tamayo","creatorNameLang":"en"}],"familyNames":[{"familyName":"渡邉","familyNameLang":"ja"},{"familyName":"ワタナベ","familyNameLang":"ja-Kana"},{"familyName":"Watanabe","familyNameLang":"en"}],"givenNames":[{"givenName":"珠代","givenNameLang":"ja"},{"givenName":"タマヨ","givenNameLang":"ja-Kana"},{"givenName":"Tamayo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"115398","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"22-1796.pdf","filesize":[{"value":"988.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22-1796.pdf","url":"https://kumadai.repo.nii.ac.jp/record/25343/files/22-1796.pdf"},"version_id":"435afc1d-fa81-4e3e-927d-a551774a496f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HIV","subitem_subject_scheme":"Other"},{"subitem_subject":"HLA","subitem_subject_scheme":"Other"},{"subitem_subject":"抗原","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"HLA-B*40:01抗原、HLA-B*40:02抗原に拘束されるHIV-1特異的CD8+ T細胞の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HLA-B*40:01抗原、HLA-B*40:02抗原に拘束されるHIV-1特異的CD8+ T細胞の解析"}]},"item_type_id":"14","owner":"1","path":["349"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-10-05"},"publish_date":"2011-10-05","publish_status":"0","recid":"25343","relation_version_is_last":true,"title":["HLA-B*40:01抗原、HLA-B*40:02抗原に拘束されるHIV-1特異的CD8+ T細胞の解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-25T07:25:24.997411+00:00"}