{"created":"2023-06-19T09:13:20.677285+00:00","id":25366,"links":{},"metadata":{"_buckets":{"deposit":"2e65371f-6bbb-4331-b372-06eb88e999b7"},"_deposit":{"created_by":127,"id":"25366","owners":[127],"pid":{"revision_id":0,"type":"depid","value":"25366"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00025366","sets":["343:347:348:349"]},"author_link":[],"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03-25","bibliographicIssueDateType":"Issued"}}]},"item_14_date_granted_74":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2010-03-25"}]},"item_14_degree_grantor_72":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"熊本大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_14_degree_name_71":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Duchenne型筋ジストロフィーは重篤な遺伝性筋疾患であり，根治治療を目指してウイルスベクターを用いた遺伝子治療が研究されている．遺伝子導入後の筋線維タイプ別でのプロモーター/エンハンサー活性を解析した報告はなく，MSCVプロモーターについても，これまでに造血幹細胞や小脳のプルキンエ細胞で安定した遺伝子発現が得られた報告はあるものの筋線維での詳細な発現効率まで検討した報告はない．本研究ではレンチウイルスベクターを用いて骨格筋への遺伝子導入を行い，導入遺伝子の発現強度を測定することでMSCVプロモーターの筋線維タイプ別の活性を評価，検討した．","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_14_dissertation_number_75":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1767号"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学","subitem_publisher_language":"ja"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"熊本大学大学院医学教育部　臨床医科学専攻"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲博医第1767号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"菅, 智宏","creatorNameLang":"ja"},{"creatorName":"スガ, トモヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Suga, Tomohiro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"22-1767.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22-1767.pdf","url":"https://kumadai.repo.nii.ac.jp/record/25366/files/22-1767.pdf"},"version_id":"9818714b-2e67-4482-990c-2d46482f771f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"筋ジストロフィー","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子治療","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"レンチウイルス","subitem_subject_language":"ja-Kana","subitem_subject_scheme":"Other"},{"subitem_subject":"MSCVプロモーター活性","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"レンチウイルスベクターを用いたマウス骨格筋遺伝子導入ならびに筋線維タイプ別のMSCVプロモーター活性の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"レンチウイルスベクターを用いたマウス骨格筋遺伝子導入ならびに筋線維タイプ別のMSCVプロモーター活性の検討","subitem_title_language":"ja"},{"subitem_title":"レンチウイルス ベクター オ モチイタ マウス コッカクキン イデンシ ドウニュウ ナラビニ キン センイ タイプ ベツ ノ MSCV プロモーター カッセイ ノ ケントウ","subitem_title_language":"ja-Kana"},{"subitem_title":"Lentiviral mediated gene therapy for mouse skeletal muscle and analysis of muscle fiber type-predominant MSCV promoter activity","subitem_title_language":"en"}]},"item_type_id":"14","owner":"127","path":["349"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-10-06"},"publish_date":"2011-10-06","publish_status":"0","recid":"25366","relation_version_is_last":true,"title":["レンチウイルスベクターを用いたマウス骨格筋遺伝子導入ならびに筋線維タイプ別のMSCVプロモーター活性の検討"],"weko_creator_id":"127","weko_shared_id":-1},"updated":"2026-01-08T06:27:08.020371+00:00"}