{"created":"2023-06-19T09:13:21.983759+00:00","id":25389,"links":{},"metadata":{"_buckets":{"deposit":"4323e028-f08e-4ca7-88ac-1e8d80677b9e"},"_deposit":{"created_by":127,"id":"25389","owners":[127],"pid":{"revision_id":0,"type":"depid","value":"25389"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00025389","sets":["343:347:354:355"]},"author_link":[],"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-25","bibliographicIssueDateType":"Issued"}}]},"item_14_date_granted_74":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2009-03-25"}]},"item_14_degree_grantor_72":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"熊本大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_14_degree_name_71":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（薬学）","subitem_degreename_language":"ja"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本研究では、M細胞を標的とする低分子化合物としてtetragalloyl-D-lysine dendrimer（TGDK）を合成し、TGDKのM細胞への標的能をin vitroヒトM細胞様モデル及びアカゲザルを用いたin vivo霊長類モデルを用いて評価した。さらに、実際にTGDKの経口ワクチン開発における応用を考慮し、polyethylene glycol（PEG）骨格を中心としたHub-Antigenに、アカゲザルCCR5の細胞外ドメインをミミックした環状ペプチド（rcDDR5）、SIVmac239の外被糖タンパク質由来のgp140、アジュバントとしてTLR9のリガンドであるCpG-ODNならびにエスコートタンパク質としてBSAをコンジュゲートしたワクチン抗原にTGDKを結合させ、アカゲザルへ経口投与し、アカゲザルの粘膜免疫の誘導ならびに感染阻害能を検討した。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_14_dissertation_number_75":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第198号"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学","subitem_publisher_language":"ja"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"熊本大学大学院薬学教育部　生命薬科学専攻"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲博薬第198号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"増山, 光明","creatorNameLang":"ja"},{"creatorName":"マスヤマ, ミツアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Masuyama, Mitsuaki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"23-0198.pdf","filesize":[{"value":"874.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"23-0198.pdf","url":"https://kumadai.repo.nii.ac.jp/record/25389/files/23-0198.pdf"},"version_id":"f6a6503a-c6dc-41c7-a145-5fd6915131e2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HIV","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"経口ワクチン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"経口HIVワクチン開発に関する薬学生化学的基礎研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"経口HIVワクチン開発に関する薬学生化学的基礎研究","subitem_title_language":"ja"},{"subitem_title":"ケイコウ HIV ワクチン カイハツ ニ カンスル ヤクガク セイカガクテキ キソ ケンキュウ","subitem_title_language":"ja-Kana"},{"subitem_title":"Biochemical Studies of HIV-oral Vaccine","subitem_title_language":"en"}]},"item_type_id":"14","owner":"127","path":["355"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-11-04"},"publish_date":"2011-11-04","publish_status":"0","recid":"25389","relation_version_is_last":true,"title":["経口HIVワクチン開発に関する薬学生化学的基礎研究"],"weko_creator_id":"127","weko_shared_id":-1},"updated":"2026-01-30T01:58:40.389535+00:00"}