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STUDY ON THE SYNTHESIS OF MACROCYCLIC COMPOUNDS USINGMANGANESE(III)-BASED OXIDATIVE RADICAL CYCLIZATION
http://hdl.handle.net/2298/22082
http://hdl.handle.net/2298/22082a63e046d-4272-4a4c-a07a-4f68b3fda241
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
25-0142.pdf (1.5 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-11-02 | |||||
| タイトル | ||||||
| タイトル | STUDY ON THE SYNTHESIS OF MACROCYCLIC COMPOUNDS USINGMANGANESE(III)-BASED OXIDATIVE RADICAL CYCLIZATION | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | thesis | |||||
| 著者 |
伊藤, 洋輔
× 伊藤, 洋輔 |
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| 別言語の著者 |
Ito, Yosuke
× Ito, Yosuke |
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| 内容記述 | ||||||
| 内容記述 | In this thesis, the oxidative macrocyclization reaction using manganese(III) acetate as an oxidant was described. The oxidation of α,α,ω,ω-tetraphenyl-α,(ω-1)-alkadienes with oligomethylene bis(3-oxobutanoate)s in the presence of manganese(III) acetate was investigated, and the novel methylene-tethered macrodiolides from twelve to sixty-two members were synthesized in good to moderate yields. A plausible mechanism for the macrocyclization was discussed. A similar reaction of oxamethylene-tethered terminal dienes with the bis(3-oxobutanoate)s gave the corresponding crown ether-type macrodiolides in acceptable yields. Since it was suggested that the cyclophane-type compounds may be available using the oxidative radical cyclization, the reaction of terminal dienes with bis(3-oxobutanoate)s containing aromatics in the methylene chain was investigated. Fortunately, a variety of the cyclophane-type macrodiolides were obtained in good to moderate yields. Furthermore, the oxidative intramolecular cyclization of (2-propenyloxy)oligomethylene and oligooxamethylene 3-oxobutanoates, and the 3-oxobutanamides were examined. As a result, the corresponding novel macrolides and macroamides were obtained in good to moderate yields. The detailed results of the study are given in Chapters 2-4, and the general procedure for the reactions and the spectroscopic data as well as the physical property of the products are given in each chapter. |
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| 書誌情報 | 発行年 2010-03-25 | |||||
| フォーマット | ||||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 1493957 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 日本十進分類法 | ||||||
| 主題 | 377.5 | |||||
| その他の言語のタイトル | ||||||
| その他のタイトル | マンガン(Ⅲ)に基づく酸化的ラジカル環化反応を用いる大環状化合物の合成に関する研究 | |||||
| タイトル（ヨミ） | ||||||
| その他のタイトル | マンガン 3 ニ モトヅク サンカテキ ラジカル カンカ ハンノウ オ モチイル ダイカンジョウ カゴウブツ ノ ゴウセイ ニ カンスル ケンキュウ | |||||
| 出版者 | ||||||
| 出版者 | 熊本大学 | |||||
| 資源タイプ | ||||||
| 内容記述 | 学位論文(Thesis) | |||||
| 資源タイプ・ローカル | ||||||
| 博士論文 | ||||||
| 資源タイプ・NII | ||||||
| Thesis or Dissertation | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
| 03 | ||||||
| コメント | ||||||
| 熊本大学大学院自然科学研究科 理学専攻 | ||||||
| 学位番号 | ||||||
| 甲博理第142号 | ||||||
