{"created":"2023-06-19T09:13:23.993044+00:00","id":25419,"links":{},"metadata":{"_buckets":{"deposit":"ebc6d762-a951-4d89-b380-159858d71f84"},"_deposit":{"created_by":127,"id":"25419","owners":[127],"pid":{"revision_id":0,"type":"depid","value":"25419"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00025419","sets":["343:347:348:349"]},"author_link":[],"control_number":"25419","item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"3020","bibliographicPageStart":"3013","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"Arteriosclerosis, Thrombosis, and Vascullar Biology"}]}]},"item_14_date_granted_74":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"1997-11"}]},"item_14_degree_grantor_72":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"熊本大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_14_degree_name_71":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Recent studies demonstrated that oxidized LDL\n(Ox-LDL) induces macrophage growth in vitro. The present study was undertaken to elucidate the intracellular signaling\npathways for macrophage growth. Ox-LDL initiated a rapid and transient rise in intracellular free calcium ion and induced\nactivation of membrane protein kinase C (PKC). Pertussis toxin completely inhibited the Ox-LDL-induced rise in free calcium ion and significantly inhibited macrophage growth by 50%. Moreover, PKC inhibitors calphostin C and H-7 significantly inhibited Ox-LDL-induced macrophage growth by 80%.\nOn the other hand, phospholipase A2-treated acetylated LDL did not induce a rise in calcium but significantly activated PKC and led to significant macrophage growth that was significantly inhibited by calphostin C by 90%. These results suggest the\npresence of two intracellular signaling pathways for activation of PKC, a rise in calcium that was mediated by pertussis\ntoxin-sensitive G protein and the internalization of lysophosphatidylcholine\nthrough the scavenger receptors. These two\npathways may play an important role in Ox-LDL-induced macrophage growth.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_14_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://atvb.ahajournals.org/content/17/11/3013.abstract","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_14_dissertation_number_75":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1195号"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学","subitem_publisher_language":"ja"}]},"item_14_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 1997 American Heart Association"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"平成11年3月25日学位取得"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲博医第1195号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松村, 剛","creatorNameLang":"ja"},{"creatorName":"マツムラ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsumura, Takeshi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"22-1195.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22-1195.pdf","url":"https://kumadai.repo.nii.ac.jp/record/25419/files/22-1195.pdf"},"version_id":"e2ed71c9-2f8c-4fba-bd29-f001b9cb5dbf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"protein kinase C","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"G proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"oxidized LDL","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage growth","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"atherosclerosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Two Intracellular Signaling Pathways for Activation of Protein Kinase C Are Involved in Oxidized Low-Density Lipoprotein-Induced Macropage Growth","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Two Intracellular Signaling Pathways for Activation of Protein Kinase C Are Involved in Oxidized Low-Density Lipoprotein-Induced Macropage Growth","subitem_title_language":"en"},{"subitem_title":"酸化低密度リポ蛋白質によるマクロファージ増殖には、2つの経路を介するプロテインキナーゼCの活性化が関与する","subitem_title_language":"ja"},{"subitem_title":"サンカ テイミツド リポ タンパクシツ ニ ヨル マクロファージ ゾウショク ニワ 2ツ ノ ケイロ オ カイスル プロテインキナーゼ C ノ カッセイカ ガ カンヨ スル","subitem_title_language":"ja-Kana"}]},"item_type_id":"14","owner":"127","path":["349"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-11-21"},"publish_date":"2011-11-21","publish_status":"0","recid":"25419","relation_version_is_last":true,"title":["Two Intracellular Signaling Pathways for Activation of Protein Kinase C Are Involved in Oxidized Low-Density Lipoprotein-Induced Macropage Growth"],"weko_creator_id":"127","weko_shared_id":-1},"updated":"2026-01-08T07:49:35.978305+00:00"}