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Epiplakin1 is expressed in the cholangiocyte lineage cells in normal liver and adult progenitor cells in injured liver
http://hdl.handle.net/2298/23335
http://hdl.handle.net/2298/23335a5919bc6-9d20-468f-9da1-d09ac3188308
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
GeneExprPatt34-11-p255–262.pdf (4.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-02-01 | |||||
| タイトル | ||||||
| タイトル | Epiplakin1 is expressed in the cholangiocyte lineage cells in normal liver and adult progenitor cells in injured liver | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Epiplakin1, Liver, Progenitor, Development, Regeneratio | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Matsuo, Akira
× Matsuo, Akira× Yoshida, Tetsu× Yasukawa, Takanori× Miki, Rika× 粂, 和彦× Kume, Shoen |
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| 別言語の著者 |
松尾, 顕
× 松尾, 顕× 吉田, 哲× 安川, 貴規× 三木, 梨可× 粂, 和彦 |
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| 内容記述 | ||||||
| 内容記述 | We have previously identified Epiplakin1 (Eppk1) as a gene expressed in pancreatic progenitor cells. Here we studied the expression of Eppk1 in developing and regenerating livers in mice. Eppk1 is initially expressed in the early bipotential hepatoblasts and is later confined to the cholangiocytes. After birth, Eppk1 is expressed in the bile duct. In the livers of mice fed with a choline-deficient ethionine-supplemented (CDE) diet, Eppk1-positive cells dramatically increase in number. The Eppk1-positive cells express A6, thereby indicating that they are hepatic progenitor cells. Other cholangiocyte markers, such as Cytokeratins, E-cadherin, osteopontin and Sox9, are also co-expressed in the hepatic progenitor cells. Some of the Eppk1-positive cells express PCNA, a proliferation marker, thereby suggesting their identities as transient amplifying cells. In conclusion, we have shown that Eppk1 serves as a useful marker for detecting the hepatic progenitor population in the developing and adult liver. The use of Eppk1 as a marker will facilitate studies of mouse hepatic progenitor cells. | |||||
| 書誌情報 |
Gene Expression Patterns 巻 11, 号 3-4, p. 255-262, 発行年 2011-03 |
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| ISSN | ||||||
| 収録物識別子 | 1567133X | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1016/j.gep.2011.01.001 | |||||
| 権利 | ||||||
| 権利情報 | 2011 Elsevier B. V. | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 4609696 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491.347 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier B.V. | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
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| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.sciencedirect.com/science/article/pii/S1567133X11000020 | |||||
