{"created":"2023-06-19T09:14:05.911043+00:00","id":26208,"links":{},"metadata":{"_buckets":{"deposit":"c4062aec-d198-4f79-abc5-136b627b526e"},"_deposit":{"created_by":1,"id":"26208","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"26208"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00026208","sets":["413:443"]},"author_link":["118261","93163"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"1724","bibliographicPageStart":"1707","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Expert Review of Neurotherapeutics"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Indo, Yasuhiro","creatorNameLang":"en"},{"creatorName":"犬童, 康弘","creatorNameLang":"ja"},{"creatorName":"インドウ, ヤスヒロ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Indo","familyNameLang":"en"},{"familyName":"犬童","familyNameLang":"ja"},{"familyName":"インドウ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yasuhiro","givenNameLang":"en"},{"givenName":"康弘","givenNameLang":"ja"},{"givenName":"ヤスヒロ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"93163","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"NGF is a well-known neurotrophic factor essential for the survival and maintenance of primary afferent neurons and sympathetic neurons. NGF is also an inflammatory mediator associated with pain and itch. Congenital insensitivity to pain with anhidrosis is a genetic disorder due to loss-of-function mutations in the NTRK1 gene encoding TrkA, a receptor tyrosine kinase for NGF. Since patients with congenital insensitivity to pain with anhidrosis lack NGF-dependent unmyelinated (C-) and thinly myelinated (Aδ-) fibers, and their dermal sweat glands are without innervation, they exhibit no pain, itch, signs of neurogenic inflammation or sympathetic skin responses. Based on the pathophysiology of congenital insensitivity to pain with anhidrosis, this article indicates how NGF-dependent neurons are essential for the establishment of neural networks for interoception and homeostasis, and play crucial roles in brain-immune-endocrine interactions in pain, itch and inflammation. In addition, it refers to involvements of the NGF-TrkA system in various disease states, and potential pharmacological effects when this system is targeted.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.expert-reviews.com/doi/abs/10.1586/ern.10.154","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Expert Reviews"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1586/ern.10.154","subitem_relation_type_select":"DOI"}}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"2010 Expert Reviews Ltd,"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"143523 bytes"},{"subitem_text_value":"148731 bytes"}]},"item_16_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_16_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal Article"}]},"item_16_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_16_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"01"}]},"item_16_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_value":"Theme: Pain - Review"}]},"item_16_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Indo, Yasuhiro"}],"nameIdentifiers":[{"nameIdentifier":"118261","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Reposit-ERN-2010-Figure.pdf","filesize":[{"value":"148.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Reposit-ERN-2010-Figure.pdf","url":"https://kumadai.repo.nii.ac.jp/record/26208/files/Reposit-ERN-2010-Figure.pdf"},"version_id":"66e3c72c-1cb2-4c9e-88a1-48848483019c"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Reposit-ERN-2010.pdf","filesize":[{"value":"143.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Reposit-ERN-2010.pdf","url":"https://kumadai.repo.nii.ac.jp/record/26208/files/Reposit-ERN-2010.pdf"},"version_id":"79370547-158b-4227-bdc9-edee26be75eb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Nerve growth factor (NGF)","subitem_subject_scheme":"Other"},{"subitem_subject":"神経成長因子","subitem_subject_scheme":"Other"},{"subitem_subject":"Receptor tyrosine kinase for NGF","subitem_subject_scheme":"Other"},{"subitem_subject":"チロシンキナーゼ型神経成長因子受容体","subitem_subject_scheme":"Other"},{"subitem_subject":"TrkA protein","subitem_subject_scheme":"Other"},{"subitem_subject":"TrkA タンパク質","subitem_subject_scheme":"Other"},{"subitem_subject":"NTRK1 gene","subitem_subject_scheme":"Other"},{"subitem_subject":"NTRK1 遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"TRKA gene","subitem_subject_scheme":"Other"},{"subitem_subject":"TRKA 遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"Congenital insensitivity to pain with anhidrosis","subitem_subject_scheme":"Other"},{"subitem_subject":"先天性無痛無汗症","subitem_subject_scheme":"Other"},{"subitem_subject":"Interoception","subitem_subject_scheme":"Other"},{"subitem_subject":"内感覚","subitem_subject_scheme":"Other"},{"subitem_subject":"Polymodal receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"ポリモーダル受容器","subitem_subject_scheme":"Other"},{"subitem_subject":"Sympathetic neuron","subitem_subject_scheme":"Other"},{"subitem_subject":"交感神経ニューロン","subitem_subject_scheme":"Other"},{"subitem_subject":"Basal forebrain cholinergic neuron","subitem_subject_scheme":"Other"},{"subitem_subject":"前脳基底野コリン作動性ニューロン","subitem_subject_scheme":"Other"},{"subitem_subject":"Emotion","subitem_subject_scheme":"Other"},{"subitem_subject":"情動","subitem_subject_scheme":"Other"},{"subitem_subject":"Pain","subitem_subject_scheme":"Other"},{"subitem_subject":"痛み","subitem_subject_scheme":"Other"},{"subitem_subject":"疼痛","subitem_subject_scheme":"Other"},{"subitem_subject":"Homeostasis","subitem_subject_scheme":"Other"},{"subitem_subject":"恒常性","subitem_subject_scheme":"Other"},{"subitem_subject":"Hereditary sensory and autonomic neuropathy type IV","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝性感覚自律神経性ニュー ロパシー IV 型","subitem_subject_scheme":"Other"},{"subitem_subject":"NGF-dependent primary afferent neuron","subitem_subject_scheme":"Other"},{"subitem_subject":"NGF 依存性一次求心性ニューロン","subitem_subject_scheme":"Other"},{"subitem_subject":"itch","subitem_subject_scheme":"Other"},{"subitem_subject":"痒み","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammation","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Nerve growth factor, pain, itch and inflammation: lessons from congenital insensitivity to pain with anhidrosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Nerve growth factor, pain, itch and inflammation: lessons from congenital insensitivity to pain with anhidrosis"}]},"item_type_id":"16","owner":"1","path":["443"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-11-15"},"publish_date":"2012-11-15","publish_status":"0","recid":"26208","relation_version_is_last":true,"title":["Nerve growth factor, pain, itch and inflammation: lessons from congenital insensitivity to pain with anhidrosis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-24T02:46:21.305454+00:00"}