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Pan-neuronal knockdown of the c-Jun N-terminal Kinase (JNK) results in a reduction in sleep and longevity in Drosophila
http://hdl.handle.net/2298/24801
http://hdl.handle.net/2298/24801a318796a-341f-447b-9fdf-0d2079eca0b0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Takahama2012BBRC-Reposit2.pdf (358.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-06-06 | |||||
| タイトル | ||||||
| タイトル | Pan-neuronal knockdown of the c-Jun N-terminal Kinase (JNK) results in a reduction in sleep and longevity in Drosophila | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | JNK, Sleep, Aging, Diet, Drosophila | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Takahama, Kazuhiro
× Takahama, Kazuhiro× Tomita, Jun× Ueno, Taro× Yamazaki, Masako× Kume, Shoen× 粂, 和彦 |
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| 別言語の著者 |
高濱, 和弘
× 高濱, 和弘× 冨田, 淳× 上野, 太郎× 山崎, 昌子× 粂, 昭苑× 粂, 和彦 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Sleep is a unique behavioral state that is conserved between species, and sleep regulation is closely associated to metabolism and aging. The fruit fly, Drosophila melanogaster has been used to study the molecular mechanism underlying these physiological processes. Here we show that the c-Jun N-terminal Kinase (JNK) gene, known as basket (bsk) in Drosophila, functions in neurons to regulate both sleep and longevity in Drosophila. Pan-neuronal knockdown of JNK mRNA expression by RNA interference resulted in a decrease in both sleep and longevity. A heterozygous knockout of JNK showed similar effects, indicating the molecular specificity. The JNK knockdown showed a normal arousal threshold and sleep rebound, suggesting that the basic sleep mechanism was not affected. JNK is known to be involved in the insulin pathway, which regulates metabolism and longevity. A JNK knockdown in insulin-producing neurons in the pars intercerebralis had slight effects on sleep. However, knocking down JNK in the mushroom body had a significant effect on sleep. These data suggest a unique sleep regulating pathway for JNK. |
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| 書誌情報 |
Biochemical and Biophysical Research Communications 巻 417, 号 2, p. 807-811, 発行年 2012-01-13 |
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| ISSN | ||||||
| 収録物識別子 | 0006291X | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1016/j.bbrc.2011.12.040 | |||||
| 権利 | ||||||
| 権利情報 | © 2012 Elsevier | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 値 | 358551 bytes | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 出版者 | ||||||
| 出版者 | Academic Press Inc | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 値 | 雑誌掲載論文 | |||||
| 資源タイプ・NII | ||||||
| 値 | Journal Article | |||||
| 資源タイプ・DCMI | ||||||
| 値 | text | |||||
| 資源タイプ・ローカル表示コード | ||||||
| 値 | 01 | |||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.sciencedirect.com/science/article/pii/S0006291X11022492 | |||||
