{"created":"2023-06-19T09:14:13.940818+00:00","id":26377,"links":{},"metadata":{"_buckets":{"deposit":"6f62d690-719a-4c0d-aa18-fb030846cbc1"},"_deposit":{"created_by":1,"id":"26377","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"26377"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00026377","sets":["407:424:467"]},"author_link":["119089","119074","92726","119087","119076","119090","119075","119085","119086","119073","119077","119088"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01-13","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"811","bibliographicPageStart":"807","bibliographicVolumeNumber":"417","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高濱, 和弘"}],"nameIdentifiers":[{"nameIdentifier":"119085","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"冨田, 淳"}],"nameIdentifiers":[{"nameIdentifier":"119086","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上野, 太郎"}],"nameIdentifiers":[{"nameIdentifier":"119087","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 昌子"}],"nameIdentifiers":[{"nameIdentifier":"119088","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"粂, 昭苑"}],"nameIdentifiers":[{"nameIdentifier":"119089","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"粂, 和彦"}],"nameIdentifiers":[{"nameIdentifier":"119090","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Sleep is a unique behavioral state that is conserved between species, and sleep\nregulation is closely associated to metabolism and aging. The fruit fly, Drosophila melanogaster has been used to study the molecular mechanism underlying these physiological processes. Here we\nshow that the c-Jun N-terminal Kinase (JNK) gene, known as basket (bsk) in Drosophila, functions in neurons to regulate both sleep and longevity in Drosophila. Pan-neuronal knockdown of JNK mRNA expression by RNA interference resulted in a decrease in both sleep and longevity. A heterozygous knockout of JNK showed similar effects, indicating the molecular specificity. The JNK knockdown showed a normal arousal threshold and sleep rebound, suggesting that the basic sleep\nmechanism was not affected. JNK is known to be involved in the insulin pathway, which regulates metabolism and longevity. A JNK knockdown in insulin-producing neurons in the pars intercerebralis had slight effects on sleep. However, knocking down JNK in the mushroom body had a significant effect on sleep. These data suggest a unique sleep regulating pathway for JNK.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science/article/pii/S0006291X11022492","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"},{"subitem_publisher":"Academic Press Inc"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bbrc.2011.12.040","subitem_relation_type_select":"DOI"}}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012 Elsevier"}]},"item_16_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006291X","subitem_source_identifier_type":"ISSN"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"358551 bytes"}]},"item_16_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_16_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal Article"}]},"item_16_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_16_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"01"}]},"item_16_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takahama, Kazuhiro"}],"nameIdentifiers":[{"nameIdentifier":"119073","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomita, Jun"}],"nameIdentifiers":[{"nameIdentifier":"119074","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ueno, Taro"}],"nameIdentifiers":[{"nameIdentifier":"119075","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamazaki, Masako"}],"nameIdentifiers":[{"nameIdentifier":"119076","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kume, Shoen"}],"nameIdentifiers":[{"nameIdentifier":"119077","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"粂, 和彦","creatorNameLang":"ja"},{"creatorName":"クメ, カズヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kume, Kazuhiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"粂","familyNameLang":"ja"},{"familyName":"クメ","familyNameLang":"ja-Kana"},{"familyName":"Kume","familyNameLang":"en"}],"givenNames":[{"givenName":"和彦","givenNameLang":"ja"},{"givenName":"カズヒコ","givenNameLang":"ja-Kana"},{"givenName":"Kazuhiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92726","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Takahama2012BBRC-Reposit2.pdf","filesize":[{"value":"358.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Takahama2012BBRC-Reposit2.pdf","url":"https://kumadai.repo.nii.ac.jp/record/26377/files/Takahama2012BBRC-Reposit2.pdf"},"version_id":"e0104504-0e2f-4be1-895d-4c5e500803ce"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"JNK","subitem_subject_scheme":"Other"},{"subitem_subject":"Sleep","subitem_subject_scheme":"Other"},{"subitem_subject":"Aging","subitem_subject_scheme":"Other"},{"subitem_subject":"Diet","subitem_subject_scheme":"Other"},{"subitem_subject":"Drosophila","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pan-neuronal knockdown of the c-Jun N-terminal Kinase (JNK) results in a reduction in sleep and longevity in Drosophila","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pan-neuronal knockdown of the c-Jun N-terminal Kinase (JNK) results in a reduction in sleep and longevity in Drosophila"}]},"item_type_id":"16","owner":"1","path":["467"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-06-06"},"publish_date":"2012-06-06","publish_status":"0","recid":"26377","relation_version_is_last":true,"title":["Pan-neuronal knockdown of the c-Jun N-terminal Kinase (JNK) results in a reduction in sleep and longevity in Drosophila"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-23T02:53:32.020350+00:00"}