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High calorie diet augments age-associated sleep impairment in Drosophila
http://hdl.handle.net/2298/24802
http://hdl.handle.net/2298/24802814edd16-8ee2-4e3c-94e4-abf52c7ceca9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Yamazaki2012BBRC-Reposit.pdf (201.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-06-06 | |||||
| タイトル | ||||||
| タイトル | High calorie diet augments age-associated sleep impairment in Drosophila | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Sleep, Locomotor activity, Aging, Diet, Dopamine, Drosophila | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Yamazaki, Masako
× Yamazaki, Masako× Tomita, Jun× Takahama, Kazuhiro× Ueno, Taro× Mitsuyoshi, Madoka× 坂本, 枝里菜× Kume, Shoen× 粂, 和彦 |
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| 別言語の著者 |
山崎, 昌子
× 山崎, 昌子× 冨田, 淳× 高濱, 和弘× 上野, 太郎× 光吉, まどか× 坂本, 枝里菜× 粂, 昭苑× 粂, 和彦 |
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| 内容記述 | ||||||
| 内容記述 | The fruit fly, Drosophila melanogaster is an established model used for aging and longevity studies and more recently for sleep studies. Mammals and Drosophila share various physiological, pathological, pharmacological and genetic similarities in these processes. In particular, sleep is essential for survival in both species and both have age-associated sleep quality alterations. Here we report that a high calorie diet, which accelerates the aging process and reduces lifespan across species, also accelerates age-associated sleep changes in Drosophila. These changes are more evident in the dopamine transporter mutant, fumin, that displays a short sleep phenotype due to enhanced dopaminergic signaling. With normal food, fumin mutants sleep for only one third of the time that the control flies do, but still show equivalent longevity. However, when on a mildly high calorie diet, their sleep length shows a marked decrease and they have a reduced longevity. These data indicate that the age-associated change in sleep in Drosophila is a physiologically regulated aging process that is tightly linked to calorie intake and that the dopamine level plays an important role. In addition, this provides another evidence that sleep is essential for the longevity of Drosophila. | |||||
| 書誌情報 |
Biochemical and Biophysical Research Communications 巻 417, 号 2, p. 812-816, 発行年 2012-01-13 |
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| ISSN | ||||||
| 収録物識別子 | 0006291X | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1016/j.bbrc.2011.12.041 | |||||
| 権利 | ||||||
| 権利情報 | © 2012 Elsevier | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 201137 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
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| 出版者 | Academic Press Inc | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
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| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.sciencedirect.com/science/article/pii/S0006291X11022509 | |||||
