{"created":"2023-06-19T09:14:23.892131+00:00","id":26581,"links":{},"metadata":{"_buckets":{"deposit":"8fb6d1ac-4c1d-4c5f-82fb-7f294af641e4"},"_deposit":{"created_by":1,"id":"26581","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"26581"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00026581","sets":["343:347:348:349"]},"author_link":["120381"],"item_14_alternative_title_22":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Investigation of the expression of cancer stem cell related molecules, Nucleostemin and Notch1, and ther roles in oral squamouse cell carcinoma"}]},"item_14_alternative_title_23":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"コウコウ ヘンペイ ジョウヒガン ニ オケル ガンカン サイボウ カンレン ブンシ Nucleostemin Notch1 ノ ハツゲント キノウ カイセキ"}]},"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-03-23","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_14_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"吉田, 遼司","creatorNameLang":"ja"},{"creatorName":"ヨシダ, リョウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshida, Ryoji","creatorNameLang":"en"}],"familyNames":[{"familyName":"吉田","familyNameLang":"ja"},{"familyName":"ヨシダ","familyNameLang":"ja-Kana"},{"familyName":"Yoshida","familyNameLang":"en"}],"givenNames":[{"givenName":"遼司","givenNameLang":"ja"},{"givenName":"リョウジ","givenNameLang":"ja-Kana"},{"givenName":"Ryoji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"120381","nameIdentifierScheme":"WEKO"}]}]},"item_14_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_14_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"学位論文(Thesis)","subitem_description_type":"Other"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"近年、様々な腫瘍で癌幹細胞(cancer stem cell; CSC)の存在やそのマーカー、および制御に関わる多くのCSC関連分子が報告されつつある。しかし、口腔扁平上皮癌(OSCC)において、病理組織標本を用いてそれらの発現様式の変化を観察、あるいは機能解析を行った報告は少ない。本研究ではOSCCの発生過程における癌幹細胞関連分子NucleosteminおよびNotch1の発現様式を明らかにするとともに、in vitroの実験からこれらの分子のOSCCにおける機能について検討した。","subitem_description_type":"Other"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"5881513 bytes"}]},"item_14_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"博士論文"}]},"item_14_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Thesis or Dissertation"}]},"item_14_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_14_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"03"}]},"item_14_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_value":"熊本大学大学院医学教育部　医学専攻"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_value":"甲博医第1828号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"吉田, 遼司","creatorNameLang":"ja"},{"creatorName":"ヨシダ, リョウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshida, Ryoji","creatorNameLang":"en"}],"familyNames":[{"familyName":"吉田","familyNameLang":"ja"},{"familyName":"ヨシダ","familyNameLang":"ja-Kana"},{"familyName":"Yoshida","familyNameLang":"en"}],"givenNames":[{"givenName":"遼司","givenNameLang":"ja"},{"givenName":"リョウジ","givenNameLang":"ja-Kana"},{"givenName":"Ryoji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"120381","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"22-1828.pdf","filesize":[{"value":"5.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22-1828.pdf","url":"https://kumadai.repo.nii.ac.jp/record/26581/files/22-1828.pdf"},"version_id":"2c8c91cc-1fb9-45ea-8656-6381afc4faa0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"口腔扁平上皮癌における癌幹細胞関連分子Nucleostemin, Notch1の発現と機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"口腔扁平上皮癌における癌幹細胞関連分子Nucleostemin, Notch1の発現と機能解析"}]},"item_type_id":"14","owner":"1","path":["349"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-07-20"},"publish_date":"2012-07-20","publish_status":"0","recid":"26581","relation_version_is_last":true,"title":["口腔扁平上皮癌における癌幹細胞関連分子Nucleostemin, Notch1の発現と機能解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-01T05:01:03.965048+00:00"}