{"created":"2023-06-19T09:14:25.600946+00:00","id":26611,"links":{},"metadata":{"_buckets":{"deposit":"6bc52c40-f860-46a9-9635-cd172620e7ee"},"_deposit":{"created_by":1,"id":"26611","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"26611"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00026611","sets":["413:443"]},"author_link":["120497","120495","120528","120501","120521","120526","120504","92462","120519","120527","120523","120525","120499","120503","120518","157974","120494","120529","120520","120524","120496","120522","120498","120500"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"30","bibliographicPageStart":"23","bibliographicVolumeNumber":"316","bibliographic_titles":[{"bibliographic_title":"Cancer Letters"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"末吉, 貴直"}],"nameIdentifiers":[{"nameIdentifier":"120518","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"城野, 博史"}],"nameIdentifiers":[{"nameIdentifier":"120519","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"神力, 悟"}],"nameIdentifiers":[{"nameIdentifier":"120520","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"太田, 和俊"}],"nameIdentifiers":[{"nameIdentifier":"120521","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"太田, 智子"}],"nameIdentifiers":[{"nameIdentifier":"120522","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田崎, 雅義"}],"nameIdentifiers":[{"nameIdentifier":"120523","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"厚山, 恵理"}],"nameIdentifiers":[{"nameIdentifier":"120524","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"薬師寺, 俊剛"}],"nameIdentifiers":[{"nameIdentifier":"120525","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"植田, 光晴"}],"nameIdentifiers":[{"nameIdentifier":"120526","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大林, 光念"}],"nameIdentifiers":[{"nameIdentifier":"120527","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"水田, 博志"}],"nameIdentifiers":[{"nameIdentifier":"120528","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安東, 由喜雄"}],"nameIdentifiers":[{"nameIdentifier":"120529","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Midkine (MK) plays important roles in tumorigenesis, however, the biological function of MK and whether MK can be a therapeutic target in osteosarcoma are unclear.  Here, we found that osteosarcoma tissues showed high MK expression.  MK knockdown by small interfering RNA significantly induced apoptosis in osteosarcoma cells, whereas recombinant MK increased cell proliferation.  Inhibition of MK signaling by anti-MK monoclonal antibody (anti-MK mAb) suppressed growth of osteosarcoma cells both in vitro and in vivo.  Moreover, inhibition of MK function significantly suppressed lung metastasis in xenograft transplantation model.  Targeting MK by anti-MK mAb may have value in the treatment of osteosarcoma.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science/article/pii/S0304383511006306","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Ireland Ltd"}]},"item_16_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"22099874","subitem_relation_type_select":"PMID"}}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.canlet.2011.10.013","subitem_relation_type_select":"DOI"}}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012 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