{"created":"2023-06-19T09:14:26.454386+00:00","id":26624,"links":{},"metadata":{"_buckets":{"deposit":"57afe6c4-5ad2-470a-a362-5330411b93e9"},"_deposit":{"created_by":1,"id":"26624","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"26624"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00026624","sets":["413:443"]},"author_link":["120573","93163"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"350","bibliographicPageStart":"341","bibliographicVolumeNumber":"82","bibliographic_titles":[{"bibliographic_title":"Clinical Genetics"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Indo, Yasuhiro","creatorNameLang":"en"},{"creatorName":"犬童, 康弘","creatorNameLang":"ja"},{"creatorName":"インドウ, ヤスヒロ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Indo","familyNameLang":"en"},{"familyName":"犬童","familyNameLang":"ja"},{"familyName":"インドウ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yasuhiro","givenNameLang":"en"},{"givenName":"康弘","givenNameLang":"ja"},{"givenName":"ヤスヒロ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"93163","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive\ngenetic disorder characterized by insensitivity to pain, anhidrosis (the inability to sweat)\nand mental retardation.\nNerve growth factor (NGF) is a well-known neurotrophic factor essential for the\nsurvival and maintenance of NGF-dependent neurons, including primary afferent\nneurons with thin fibers and sympathetic postganglionic neurons, during development.\nNGF is also considered to be an inflammatory mediator associated with pain, itch and\ninflammation in adults.\nCIPA results from loss-of-function mutations in the NTRK1 gene-encoding TrkA\n(tropomyosin-related kinase A), a receptor tyrosine kinase for NGF. Defects in\nNGF-TrkA signal transduction lead to the failure of survival of various NGF-dependent\nneurons. As a result, patients with CIPA lack NGF-dependent neurons. Recent studies\nhave revealed that mutations in the NGFB gene-encoding NGF protein also cause\ncongenital insensitivity to pain.Using the pathophysiology of CIPA as a foundation, this review investigates the ways\nin which NGF-dependent neurons contribute to interoception, homeostasis and\nemotional responses and, together with the brain, immune and endocrine systems, play\ncrucial roles in pain, itch and inflammation.\nThe NGF-TrkA system is essential for the establishment of neural networks for\ninteroception, homeostasis and emotional responses. These networks mediate reciprocal\ncommunication between the brain and the body in humans.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://onlinelibrary.wiley.com/doi/10.1111/j.1399-0004.2012.01943.x/abstract","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Blackwell Publishing"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/j.1399-0004.2012.01943.x","subitem_relation_type_select":"DOI"}}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012 Blackwell Publishing"}]},"item_16_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00099163","subitem_source_identifier_type":"ISSN"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"162422 bytes"},{"subitem_text_value":"593020 bytes"},{"subitem_text_value":"81680 bytes"},{"subitem_text_value":"112838 bytes"},{"subitem_text_value":"98777 bytes"},{"subitem_text_value":"167915 bytes"}]},"item_16_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_16_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal 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kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Reposit-CG-2012F1.pdf","url":"https://kumadai.repo.nii.ac.jp/record/26624/files/Reposit-CG-2012F1.pdf"},"version_id":"efdf48d4-6be7-42f7-b380-0b9e2287f637"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Reposit-CG-2012.pdf","filesize":[{"value":"162.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Reposit-CG-2012.pdf","url":"https://kumadai.repo.nii.ac.jp/record/26624/files/Reposit-CG-2012.pdf"},"version_id":"8321fd55-4692-49a5-8ab5-bd46a9e0ff02"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"congenital insensitivity to pain (CIP)","subitem_subject_scheme":"Other"},{"subitem_subject":"congenital insensitivity to pain with anhidrosis (CIPA)","subitem_subject_scheme":"Other"},{"subitem_subject":"hereditary sensory and autonomic neuropathy type IV","subitem_subject_scheme":"Other"},{"subitem_subject":"interoception","subitem_subject_scheme":"Other"},{"subitem_subject":"NGF-dependent primary afferent neurons","subitem_subject_scheme":"Other"},{"subitem_subject":"NTRK1 gene","subitem_subject_scheme":"Other"},{"subitem_subject":"polymodal receptors","subitem_subject_scheme":"Other"},{"subitem_subject":"receptor tyrosine kinase for NGF","subitem_subject_scheme":"Other"},{"subitem_subject":"sympathetic neurons","subitem_subject_scheme":"Other"},{"subitem_subject":"TrkA receptor","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Nerve Growth Factor and the Physiology of Pain: Lessons from Congenital Insensitivity to Pain with Anhidrosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Nerve Growth Factor and the Physiology of Pain: Lessons from Congenital Insensitivity to Pain with Anhidrosis"}]},"item_type_id":"16","owner":"1","path":["443"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-09-27"},"publish_date":"2012-09-27","publish_status":"0","recid":"26624","relation_version_is_last":true,"title":["Nerve Growth Factor and the Physiology of Pain: Lessons from Congenital Insensitivity to Pain with Anhidrosis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-24T02:46:20.914690+00:00"}