{"created":"2023-06-19T09:14:26.770726+00:00","id":26629,"links":{},"metadata":{"_buckets":{"deposit":"bcf60ba4-f536-4fb5-b14a-5d11e3d2f994"},"_deposit":{"created_by":127,"id":"26629","owners":[127],"pid":{"revision_id":0,"type":"depid","value":"26629"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00026629","sets":["413:443"]},"author_link":[],"item_16_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"409","bibliographicPageStart":"405","bibliographicVolumeNumber":"163","bibliographic_titles":[{"bibliographic_title":"Virus Research","bibliographic_titleLang":"en"}]}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Hepatitis C virus (HCV) elevated expression of the translocase of outer mitochondrial\n membrane 70 (Tom70). Interestingly, overexpression of Tom70 induces interferon (IFN) synthesis in hepatocytes, and it was impaired by HCV. Here, we addressed the mechanism of this impairment. The HCV NS3/4A protein induced Tom70 expression. The HCV NS3 protein interacted in cells, and cleaved the adapter protein mitochondrial anti-viral signaling (MAVS).\nEctopic overexpression of Tom70 could not inhibit this cleavage. As a result, IRF-3\nphosphorylation was impaired and IFN-β induction was suppressed. These results indicate that\nMAVS works upstream of Tom70 and the cleavage of MAVS by HCV NS3 protease suppresses signaling of IFN induction.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_16_relation_61":{"attribute_name":"関連","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.virusres.2011.10.009","subitem_relation_type_select":"DOI"}}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2012 Elsevier","subitem_rights_language":"en"}]},"item_16_source_id_7":{"attribute_name":"item_16_source_id_7","attribute_value_mlt":[{"subitem_source_identifier":"0168-1702","subitem_source_identifier_type":"PISSN"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_16_version_type_19":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kasama, Yuri","creatorNameLang":"en"},{"creatorName":"笠間, 由里","creatorNameLang":"ja"},{"creatorName":"カサマ, ユリ","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"Saito, Makoto","creatorNameLang":"en"},{"creatorName":"齋藤, 誠 ","creatorNameLang":"ja"},{"creatorName":"サイトウ, マコト","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"Takano, Takashi","creatorNameLang":"en"},{"creatorName":"高野, 隆 ","creatorNameLang":"ja"},{"creatorName":"タカノ, タカシ","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"Nishimura, Tomohiro","creatorNameLang":"en"},{"creatorName":"西村, 知裕","creatorNameLang":"ja"},{"creatorName":"ニシムラ, トモヒロ","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"Satoh, Masaaki","creatorNameLang":"en"},{"creatorName":"佐藤, 正明","creatorNameLang":"ja"},{"creatorName":"サトウ, マサアキ","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"Wang, Zhongzhi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Salem Nagla Elwy Salem Ali","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Harada, Shinji","creatorNameLang":"en"},{"creatorName":"原田, 信志","creatorNameLang":"ja"},{"creatorName":"ハラダ, シンジ","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"Kohara, Michinori","creatorNameLang":"en"},{"creatorName":"小原, 道法","creatorNameLang":"ja"},{"creatorName":"コハラ, ミチノリ","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"Kohara, Kyoko","creatorNameLang":"en"},{"creatorName":"小原, 恭子","creatorNameLang":"ja"},{"creatorName":"コハラ, キョウコ","creatorNameLang":"ja-Kana"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Virus Research2012.VOL163.pdf","filesize":[{"value":"564.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Virus Research2012.VOL163.pdf","url":"https://kumadai.repo.nii.ac.jp/record/26629/files/Virus Research2012.VOL163.pdf"},"version_id":"1dd17b0c-3731-4f72-9e65-a3b3de6eadb5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HCV","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tom70","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MAVS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IFN","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IRF-3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NS3","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Translocase of outer mitochondrial membrane 70 induces interferon response and is impaired by hepatitis C virus NS3","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Translocase of outer mitochondrial membrane 70 induces interferon response and is impaired by hepatitis C virus NS3","subitem_title_language":"en"}]},"item_type_id":"16","owner":"127","path":["443"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-10-25"},"publish_date":"2012-10-25","publish_status":"0","recid":"26629","relation_version_is_last":true,"title":["Translocase of outer mitochondrial membrane 70 induces interferon response and is impaired by hepatitis C virus NS3"],"weko_creator_id":"127","weko_shared_id":-1},"updated":"2025-05-01T07:16:01.071642+00:00"}