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Salvage treatment with temozolomide in refractory or relapsed primary central nervous system lymphoma and assessment of the MGMT status
http://hdl.handle.net/2298/27101
http://hdl.handle.net/2298/27101388757ca-97d0-4d2e-89cb-e0c10b63c891
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-03-01 | |||||
| タイトル | ||||||
| タイトル | Salvage treatment with temozolomide in refractory or relapsed primary central nervous system lymphoma and assessment of the MGMT status | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | primary central nervous system lymphoma, salvage chemotherapy, temozolomide, MGMT | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Makino, Keishi
× Makino, Keishi× Nakamura, Hideo× Hide, Taku-ichiro× Kuratsu, Jun-ichi |
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| 別言語の著者 |
牧野, 敬史
× 牧野, 敬史× 中村, 英夫× 秀, 拓一郎× 倉津, 純一 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | High-dose methotrexate (HD-MTX) is effective in the initial treatment of primary central nervous system lymphoma (PCNSL). Since the treatment options in patients with progressive or recurrent PCNSL are limited, their prognosis is remains poor. Temozolomide, a well-tolerated oral alkylating agent that permeates the blood brain barrier, is effective against malignant glioma and recurrent PCNSL. The gene for the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT), which is closely related to cellular sensitivity to alkylating agents, is inactivated by promoter hypermethylation. We evaluated the results of temozolomide treatment and the methylation status of the promoter region of the MGMT gene in 17 patients (median age 68 years) with refractory or relapsed PCNSL. They were immunocompetent and had received initial treatment with HD-MTX (3.5 g/m2) with or without irradiation. All were treated with temozolomide 150 to 200 mg/m2, for 5 days in the course of 28 days; treatment was continued until disease progression. We observed 5 complete remissions, 5 partial responses and stable disease, and 7 disease progressions. Median overall survival after the temozolomide treatment was 6.7 months. One patient manifested grade 3 neutropenia and thrombocytopenia. Eleven tumor specimens were available for MGMT analysis. MGMT promoter methylation (mMGMT) in the tumor tissue was found in 4 (36.4%), the other 7 harbored a non-methylated MGMT promoter (nmMGMT). There was no statistically significant difference in median overall survival between patients with mMGMT (11.1 months) and nmMGMT (6.7 months)(p=0.63). Although some patients were elderly and had been heavily pre-treated, temozolomide produced a complete response in 29% and was well tolerated without any major toxicity. | |||||
| 書誌情報 |
Journal of Neuro-Oncology 巻 106, 号 1, p. 155-160, 発行年 2012-01 |
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| ISSN | ||||||
| 収録物識別子 | 0167594X | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 21720808 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1007/s11060-011-0652-z | |||||
| 権利 | ||||||
| 権利情報 | © 2012 Springer Verlag | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493.2 | |||||
| 出版者 | ||||||
| 出版者 | Kluwer Academic Publishers | |||||
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| 出版者 | Springer Verlag | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
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| 値 | 雑誌掲載論文 | |||||
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| 値 | 01 | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | http://link.springer.com/article/10.1007%2Fs11060-011-0652-z | |||||
