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Development of type 2 diabetes caused by a deficiency of a tRNAlys modification
http://hdl.handle.net/2298/25749
http://hdl.handle.net/2298/25749caf09cca-db59-480d-a976-b0bb84f22ebb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Islets,4,1,71-73.pdf (74.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-10-25 | |||||
| タイトル | ||||||
| タイトル | Development of type 2 diabetes caused by a deficiency of a tRNAlys modification | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Cdkal1, ER stress, Islet, Translation, tRNA | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Wei, Fan-Yan
× Wei, Fan-Yan× Tomizawa, Kazuhito |
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| 別言語の著者 |
魏, 范研
× 魏, 范研× 富澤, 一仁 |
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| 内容記述 | ||||||
| 内容記述 | Genetic variations in the cdk5 regulator associated protein 1-like 1 (cdkal1) gene have been identified in whole genome association studies as a risk factor for the development of type 2 diabetes (T2D). A recent study showed that Cdkal1 was a mammalian methythiotransferase, which specifically synthesizes 2-methylthio-N 6-threonylcarbamoyladenosine (ms 2t 6A) at position 37 of tRNA lys(UUU). The ms 2t 6A modification in tRNA lys(UUU) was important for the accurate decoding of its cognate codon. In pancreatic β-cell-specific Cdkal1 knockout (Cdkal1 KO) mice, a deficiency of ms 2t 6A caused the mistranslation of a Lys codon in proinsulin, resulting in improper processing. The mice showed a decrease in insulin secretion and glucose intolerance. In addition, the mistranslation contributed to the expression of the endoplasmic reticulum (ER) stress response in Cdkal1-deficient β-cells. Furthermore, Cdkal1 KO mice were hypersensitive to high-fat diet-induced glucose intolerance, as well as the ER stress response. These findings might potentially explain the molecular pathogenesis of T2D in patients carrying Cdkal1 variations. | |||||
| 書誌情報 |
Islets 巻 4, 号 1, p. 71-73, 発行年 2012-01 |
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| ISSN | ||||||
| 収録物識別子 | 19382014 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.4161/isl.18262 | |||||
| 権利 | ||||||
| 権利情報 | © 2012 Landes Bioscience | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 74875 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493 | |||||
| 出版者 | ||||||
| 出版者 | Landes Bioscience | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
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| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.landesbioscience.com/journals/islets/article/18262/ | |||||
