{"created":"2023-06-19T09:14:27.158280+00:00","id":26636,"links":{},"metadata":{"_buckets":{"deposit":"dd972b7f-69d2-4264-982d-bfe29ac4b148"},"_deposit":{"created_by":1,"id":"26636","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"26636"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00026636","sets":["413:443"]},"author_link":["120768","120767","120769","120766","120770"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"73","bibliographicPageStart":"71","bibliographicVolumeNumber":"4","bibliographic_titles":[{"bibliographic_title":"Islets"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"魏, 范研"}],"nameIdentifiers":[{"nameIdentifier":"120769","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"富澤, 一仁"}],"nameIdentifiers":[{"nameIdentifier":"120770","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Genetic variations in the cdk5 regulator associated protein 1-like 1 (cdkal1) gene have been identified in whole genome association studies as a risk factor for the development of type 2 diabetes (T2D). A recent study showed that Cdkal1 was a mammalian methythiotransferase, which specifically synthesizes 2-methylthio-N 6-threonylcarbamoyladenosine (ms 2t 6A) at position 37 of tRNA lys(UUU). The ms 2t 6A modification in tRNA lys(UUU) was important for the accurate decoding of its cognate codon. In pancreatic β-cell-specific Cdkal1 knockout (Cdkal1 KO) mice, a deficiency of ms 2t 6A caused the mistranslation of a Lys codon in proinsulin, resulting in improper processing. The mice showed a decrease in insulin secretion and glucose intolerance. In addition, the mistranslation contributed to the expression of the endoplasmic reticulum (ER) stress response in Cdkal1-deficient β-cells. Furthermore, Cdkal1 KO mice were hypersensitive to high-fat diet-induced glucose intolerance, as well as the ER stress response. These findings might potentially explain the molecular pathogenesis of T2D in patients carrying Cdkal1 variations.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.landesbioscience.com/journals/islets/article/18262/","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Landes Bioscience"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.4161/isl.18262","subitem_relation_type_select":"DOI"}}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012 Landes Bioscience"}]},"item_16_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"19382014","subitem_source_identifier_type":"ISSN"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"74875 bytes"}]},"item_16_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_16_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal Article"}]},"item_16_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_16_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"01"}]},"item_16_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wei, Fan-Yan"}],"nameIdentifiers":[{"nameIdentifier":"120766","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomizawa, Kazuhito"}],"nameIdentifiers":[{"nameIdentifier":"120767","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Islets,4,1,71-73.pdf","filesize":[{"value":"74.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Islets,4,1,71-73.pdf","url":"https://kumadai.repo.nii.ac.jp/record/26636/files/Islets,4,1,71-73.pdf"},"version_id":"777b099d-f198-4908-b2cd-8f4d17bea549"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cdkal1","subitem_subject_scheme":"Other"},{"subitem_subject":"ER stress","subitem_subject_scheme":"Other"},{"subitem_subject":"Islet","subitem_subject_scheme":"Other"},{"subitem_subject":"Translation","subitem_subject_scheme":"Other"},{"subitem_subject":"tRNA","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Development of type 2 diabetes caused by a deficiency of a tRNAlys modification","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Development of type 2 diabetes caused by a deficiency of a tRNAlys modification"}]},"item_type_id":"16","owner":"1","path":["443"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-10-25"},"publish_date":"2012-10-25","publish_status":"0","recid":"26636","relation_version_is_last":true,"title":["Development of type 2 diabetes caused by a deficiency of a tRNAlys modification"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T17:48:49.151894+00:00"}