@article{oai:kumadai.repo.nii.ac.jp:00026637,
 author = {林, 光博 and 山本, 豊 and 指宿, 睦子 and 藤原, 沙織 and 山本, 聡子 and Yamamoto, Satoko and 冨田, さおり and 中野, 正啓 and 村上, 敬一 and Murakami, Keiichi and 猪山, 賢一 and 岩瀬, 弘敬 and Hayashi, Mitsuhiro and 山本, 豊 and Yamamoto, Yutaka and Ibusuki, Mutsuko and Fujiwara, Saori and 山本, 聡子 and Yamamoto, Satoko and Tomita, Saori and Nakano, Masahiro and 村上, 敬一 and Murakami, Keiichi and Iyama, Kenichi and Iwase, Hirotaka},
 issue = {9},
 journal = {Annals of Surgical Oncology},
 month = {Sep},
 note = {application/pdf, 論文(Article), Background: Breast elastography (EG), which can objectively evaluate tumor stiffness, has been useful for differentiation of benign and malignant breast lesions. However, the value of EG for prediction of response to systemic therapy is poorly understood.
Methods: The baseline evaluations of EG in 55 patients who received neoadjuvant chemotherapy were reviewed. We investigated the correlation between tumor stiffness and response to neoadjuvant chemotherapy. Tumor stiffness was evaluated using the Tsukuba elasticity scoring system.
Results: The mean EG scores were significant lower for the clinical and pathological complete response (pCR) groups than for the others. When we categorized patients into two groups according to tumor stiffness, 26 patients were assigned to the low EG group (soft, scores from I to III) and 29 patients were assigned to the high EG group (hard, score IV and V). The low EG group had significantly higher clinical CR and pCR rates than the high EG group (clinical CR, low EG group 38% vs. high EG group 10%, P = 0.024; pCR, low EG group 50% vs. high EG group 14%, P = 0.003, respectively). Furthermore, multivariate analysis indicated that ER, HER2, and low EG (odds ratio 13.04, 95% CI 1.19 to 458.28, P = 0.035) were independent predictive factors of pCR.
Conclusion: Our data demonstrate that tumor stiffness evaluated by EG bears predictive potential for response to neoadjuvant chemotherapy. Stiffness evaluated by EG may be recognized as a clinically significant tumor characteristic, comparable to other data obtained by functional imaging techniques., http://link.springer.com/article/10.1245%2Fs10434-012-2343-1},
 pages = {3042--3049},
 title = {Evaluation of tumor stiffness by elastography is predictive for pathologic complete response to neoadjuvant chemotherapy in patients with breast cancer},
 volume = {19},
 year = {2012},
 yomi = {ヤマモト, サトコ and ムラカミ, ケイイチ and ヤマモト, ユタカ and ヤマモト, サトコ and ムラカミ, ケイイチ}
}