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Dopamine Modulates Metabolic Rate and Temperature Sensitivity in Drosophila melanogaster
http://hdl.handle.net/2298/25962
http://hdl.handle.net/2298/259628b8b6f4d-f9d5-42b2-87d0-2a65afc02c64
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PLOS ONE 2012VOL7-2.pdf (476.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-11-30 | |||||
| タイトル | ||||||
| タイトル | Dopamine Modulates Metabolic Rate and Temperature Sensitivity in Drosophila melanogaster | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Ueno, Taro
× Ueno, Taro× Tomita, Jun× Kume, Shoen× 粂, 和彦 |
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| 別言語の著者 |
上野, 太郎
× 上野, 太郎× 冨田, 淳× 粂, 昭苑× 粂, 和彦 |
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| 内容記述 | ||||||
| 内容記述 | Homeothermal animals, such as mammals, maintain their body temperature by heat generation and heat dissipation, while poikilothermal animals, such as insects, accomplish it by relocating to an environment of their favored temperature. Catecholamines are known to regulate thermogenesis and metabolic rate in mammals, but their roles in other animals are poorly understood. The fruit fly, Drosophila melanogaster, has been used as a model system for the genetic studies of temperature preference behavior. Here, we demonstrate that metabolic rate and temperature sensitivity of some temperature sensitive behaviors are regulated by dopamine in Drosophila. Temperature-sensitive molecules like dTrpA1 and shits induce temperaturedependent behavioral changes, and the temperature at which the changes are induced were lowered in the dopamine transporter-defective mutant, fumin. The mutant also displays a preference for lower temperatures. This thermophobic phenotype was rescued by the genetic recovery of the dopamine transporter in dopamine neurons. Flies fed with a dopamine biosynthesis inhibitor (3-iodo-L-tyrosine), which diminishes dopamine signaling, exhibited preference for a higher temperature. Furthermore, we found that the metabolic rate is upregulated in the fumin mutant. Taken together, dopamine has functions in the temperature sensitivity of behavioral changes and metabolic rate regulation in Drosophila, as well as its previously reported functions in arousal/sleep regulation. |
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| 書誌情報 |
PLOS ONE 巻 7, 号 2, p. 1-16, 発行年 2012-02-07 |
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| ISSN | ||||||
| 収録物識別子 | 19326203 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 関連識別子 | 10.1371/journal.pone.0031513 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 476402 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491 | |||||
| 出版者 | ||||||
| 出版者 | Public Library of Science | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
| 01 | ||||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0031513 | |||||
