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Pseudohypacusis in childhood and adolescence is associated with increased gray matter volume in the medial frontal gyrus and superior temporal gyrus
http://hdl.handle.net/2298/26062
http://hdl.handle.net/2298/260623d742f49-a53a-40f4-92e8-63b7465612ce
| 名前 / ファイル | ライセンス | アクション |
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Cortex.48.4.492-503-Figure.pdf (244.5 kB)
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Cortex.48.4.492-503.pdf (107.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-12-13 | |||||
| タイトル | ||||||
| タイトル | Pseudohypacusis in childhood and adolescence is associated with increased gray matter volume in the medial frontal gyrus and superior temporal gyrus | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Pseudohypacusis, Somatoform disorder, Voxel-based morphometry, Medial frontal gyrus (Brodmann area 10), Superior temporal gyrus (Brodmann area 42) | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
友田, 明美
× 友田, 明美× Kinoshita, Sumihito× Korenaga, Yuki× Mabe, Hiroyo |
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| 別言語の著者 |
友田, 明美
× 友田, 明美× 木下, 澄仁× 是永, 有希× 間部, 裕代 |
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| 内容記述 | ||||||
| 内容記述 | Pseudohypacusis is a somatoform disorder characterized by hearing loss with discrepancies between pure-tone audiometry and auditory brainstem response (ABR), but the underlying neuronal mechanisms remain unclear. Using voxel-based morphometry (VBM) with magnetic resonance (MR) imaging for 14 unmedicated, right-handed patients and 35 healthy control subjects, we investigated whether functional hearing loss was associated with discernible changes of brain morphology. Group differences in gray matter volume (GMV) were assessed using high-resolution, T1-weighted, volumetric MR imaging datasets (3T Trio scanner; Siemens AG) and analyzed with covariant factors of age, sex, socioeconomic status (SES), and total GMV, which was increased by 27.9% in the left medial frontal gyrus (MFG) (Brodmann area 10) (p=.001, corrected cluster level) and by 14.4% in the right superior temporal gyrus (STG) and the adjacent middle temporal gyrus (MTG) (BA42 to 21) (p=.009, corrected cluster level) in patients with pseudohypacusis. The GMV in the right STG (BA42) and verbal intelligence quotient (IQ) were correlated significantly with the Wechsler Intelligence Scale for Children – Third Edition (WISC-III) (ß=−.57, p<.0001) and level of SES (ß=−.55, p<.0001). The present findings suggest that the development of the auditory association cortex involved in language processing is affected, causing insufficient pruning during brain development. We therefore assert that differences in the neuroanatomical substrate of pseudohypacusis subjects result from a developmental disorder in auditory processing. | |||||
| 書誌情報 |
Cortex 巻 48, 号 4, p. 492-503, 発行年 2012-04 |
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| ISSN | ||||||
| 収録物識別子 | 00109452 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 21074149 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1016/j.cortex.2010.10.001 | |||||
| 権利 | ||||||
| 権利情報 | © 2012 Elsevier | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 107418 bytes | ||||||
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| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 377.5 | |||||
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| 出版者 | Elsevier | |||||
| 出版者 | ||||||
| 出版者 | Masson SpA | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.sciencedirect.com/science/article/pii/S001094521000242X@@@http://www.cortexjournal.net/article/S0010-9452%2810%2900242-X/abstract | |||||
