@article{oai:kumadai.repo.nii.ac.jp:00026706, author = {山下, 賢 and 坂口, 秀哉 and 森, 麗 and 木村, 円 and 前田, 寧 and 平野, 照之 and 内野, 誠 and Yamashita, Satoshi and Sakaguchi, Hideya and Mori, Akira and 木村, 円 and Kimura, En and Maeda, Yasushi and Hirano, Teruyuki and Uchino, Makoto}, issue = {3}, journal = {Muscle and Nerve}, month = {Mar}, note = {application/pdf, application/pdf, 論文(Article), Introduction: Several studies have shown a significant amplitude decrement in compound muscle action potentials (CMAP) on repetitive nerve stimulation (RNS) of muscles involved in ALS. In ALS, muscle wasting preferentially affects the thenar muscles (APB) rather than the hypothenar muscles (ADM). Methods: We performed RNS studies in the APB and ADM muscles of 32 ALS patients to determine whether the effect of RNS differs between the median and ulnar nerves. Results: The decremental responses to RNS were greater in the APB than in the ADM. Reduced CMAP amplitude was negatively correlated with CMAP decrement in median but not in ulnar nerves. Discussion: The greater CMAP decrement in median nerve was attributed to preferential involvement of the APB in the pathophysiology of ALS or some underlying difference in the biology of the two muscles/nerves. Further investigation may further our understanding of the pathophysiology of ALS., http://onlinelibrary.wiley.com/doi/10.1002/mus.22301/abstract}, pages = {426--428}, title = {Significant CMAP decrement by repetitive nerve stimulation is more frequent in median than ulnar nerves of patients with amyotrophic lateral sclerosis}, volume = {45}, year = {2012}, yomi = {キムラ, エン} }