{"created":"2023-06-19T09:14:44.646947+00:00","id":26973,"links":{},"metadata":{"_buckets":{"deposit":"d181365e-d2e4-434c-a65a-f7bcf9fa8ad5"},"_deposit":{"created_by":1,"id":"26973","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"26973"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00026973","sets":["343:347:348:497"]},"author_link":["122477","122478","122479"],"item_14_alternative_title_22":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"SMS1欠損マウスにおける難聴"}]},"item_14_alternative_title_23":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"SMS1 ケッソン マウス ニオケル ナンチョウ"}]},"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-09-25","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_14_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Lu, Mei-Hong"}],"nameIdentifiers":[{"nameIdentifier":"122479","nameIdentifierScheme":"WEKO"}]}]},"item_14_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_14_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"学位論文(Thesis)","subitem_description_type":"Other"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Sphingomyelin (SM), a major species of sphingolipids, is a ubiquitous component of\ncell membranes and plays vital roles in signal transduction and cell growth and survival.\nHowever, its physiological functions have not been fully elucidated. Here we have\nexamined the role of SM synthesis mediated by SM synthase (SMS) family members,\nSMS1 and SMS2, in auditory function. Hearing ability of SMS1 null mice, assessed\nwith an association learning experiment and with auditory brainstem response, was\nimpaired, especially at low frequency range; the impairment was accompanied by\nabnormalities of stria vascularis (SV), i.e., a decrease in the width of SV and a\ndisorganization of marginal cells. Further, fluorescent immunostaining and western\nblotting revealed an altered expression pattern and reduced level of KCNQ1 channels in\nmarginal cells. In addition, SMS1 knockout (KO) mice exhibited a significant decrease\nof endocochlear potential and distortion product otoacoustic emissions, suggesting the\ndefects of cochlear functions. And observation of more macrophage invasion into SV at\napical region than other regions may explain the low frequency hearing loss in these\nSMS1 KO mice. Mice lacking SMS2, however, showed no detectable hearing loss.\nTaken together, our results suggest hearing impairment in SMS1 deficient mice but not\nin SMS2 deficient mice. Defects in SV may at least in part account for the hearing\nimpairment in SMS1 deficient mice.","subitem_description_type":"Other"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"10236877 bytes"}]},"item_14_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"博士論文"}]},"item_14_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Thesis or Dissertation"}]},"item_14_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_14_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"03"}]},"item_14_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_value":"熊本大学大学院医学教育部 医学専攻"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_value":"甲博生命第14号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"呂, 美紅"}],"nameIdentifiers":[{"nameIdentifier":"122477","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"51-0014.pdf","filesize":[{"value":"10.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"51-0014.pdf","url":"https://kumadai.repo.nii.ac.jp/record/26973/files/51-0014.pdf"},"version_id":"7c655a6b-9aee-44d8-92d7-b02d47ec6d39"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Hearing impairment in SMS1 deficient mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hearing impairment in SMS1 deficient mice"}]},"item_type_id":"14","owner":"1","path":["497"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-02-01"},"publish_date":"2013-02-01","publish_status":"0","recid":"26973","relation_version_is_last":true,"title":["Hearing impairment in SMS1 deficient mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T17:46:15.215764+00:00"}