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Strain difference of cadmium-induced testicular toxicity in inbred Wistar-Imamichi and Fischer 344 rats
http://hdl.handle.net/2298/27222
http://hdl.handle.net/2298/2722211140bdb-251f-4a06-9878-0345cd49f475
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-03-08 | |||||
| タイトル | ||||||
| タイトル | Strain difference of cadmium-induced testicular toxicity in inbred Wistar-Imamichi and Fischer 344 rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Cd, Testicular toxicity, Strain difference, Rat, Zn | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
島田, 秀昭
× 島田, 秀昭× Narumi, Rika× Nagano, Masaaki× Yasutake, Akira× Waalkes, Michael P.× 今村, 順茂 |
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| 別言語の著者 |
島田, 秀昭
× 島田, 秀昭× 鳴海, 里加× 永野, 匡昭× 安武, 章× Waalkes, Michael P. |
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| 内容記述 | ||||||
| 内容記述 | Previously, we reported that Wistar-Imamichi (WI) rats are highly resistance to cadmium (Cd)-induced lethality and hepatotoxicity compared to Fischer 344 (F344) rats. Since the testes are one of the most sensitive organs to acute Cd toxicity, we examined possible strain-related differences in Cd-induced testicular toxicity between inbred WI and F344 rats. Rats were treated with a single dose of 0.5, 1.0 or 2.0 mg Cd/kg, as CdCl2, sc and killed at 24 h later. Cd at doses of 1.0 and 2.0 mg/kg induced severe testicular hemorrhage, as assessed by pathologically and testis hemoglobin content, in F344 rats, but not WI rats. After Cd treatment (2.0 mg/kg), testicular Cd content was significantly lower in WI rats than in the F344 rats, indicating a toxiokinetic mechanism for the observed strain difference. Thus, the remarkable resistance to Cd-induced testicular toxicity in WI rats is associated, at least in part, with lower testicular accumulation of Cd. When zinc (Zn; 10 mg/kg, sc) was administered in combination with Cd (2.0 mg/kg) to F344 rats, the Cd-induced increase in testicular hemoglobin content, indicative of hemorrhage, was significantly reduced. Similarly, testicular Cd content was significantly decreased with Zn co-treatment compared to Cd treatment alone. Thus, it can be concluded that testicular Cd accumulation partly competes with Zn transport systems and that these systems may play an important role in the strain-related differences in Cd-induced testicular toxicity between WI and F344 rats. | |||||
| 書誌情報 |
Archives of Toxicology 巻 83, 号 7, p. 647-652, 発行年 2009-07 |
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| ISSN | ||||||
| 収録物識別子 | 03405761 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 19479238 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1007/s00204-009-0442-y | |||||
| 権利 | ||||||
| 権利情報 | © 2009 Springer Verlag | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493 | |||||
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| 出版者 | Springer Verlag | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
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| 雑誌掲載論文 | ||||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | http://link.springer.com/article/10.1007%2Fs00204-009-0442-y | |||||
