@article{oai:kumadai.repo.nii.ac.jp:00027312,
 author = {島田, 秀昭 and 山岡, 勇介 and 森田, 怜子 and 水野, 貴之 and Gotoh, Kousei and Goto, Kousei and 樋口, 敏幸 and 白石, 隆幸 and 今村, 順茂 and Shimada, Hideaki and Yamaoka, Yusuke and Morita, Reiko and Mizuno, Takayuki and Gotoh, Kousei and Goto, Kousei and Higuchi, Toshiyuki and Shiraishi, Takayuki and Imamura, Yorishige},
 issue = {2},
 journal = {Toxicology in Vitro},
 month = {Mar},
 note = {application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, 論文(Article), The purpose of this study is to elucidate the possible mechanism of superoxide formation through redox cycling of plumbagin (PLG) in pig heart. Of four 1,4-naphthoquinonestested in this study, PLG was most efficiently reduced in the cytosolic fraction of pig heart. On the other hand, lawsone (LAS) was little reduced. Thus, whether or not PLG and LAS induce the formation of superoxide anion radical in pig heart cytosol was examined, by using the methods of cytochrome c reduction and chemiluminescence. PLG significantly induced the formation of superoxide anion radical, even though LAS had no ability to mediate superoxide formation. PLG was a significant inhibitor for the stereoselective reduction of 4-benzoylpyridine (4-P)catalyzed bytetrameric carbonyl reductase (TCBR) in pig heart cytosol. Furthermore, PLG was confirmed to competitively inhibit the 4-BP reduction, and the optimal pH for the PLG reduction was around 6.0 similar to that for the 4-BP reduction. These results suggest that PLG mediates superoxide formation through its redox cycling involved in the two-electron reduction catalyzed by TCBR, and induces oxidative stress in pig heart., http://www.sciencedirect.com/science/article/pii/S0887233311003237},
 pages = {252--257},
 title = {Possible mechanism of superoxide formation through redox cycling of plumbagin in pig heart},
 volume = {26},
 year = {2012},
 yomi = {シマダ, ヒデアキ and モリタ, レイコ and ゴトウ, コウセイ and イマムラ, ヨリシゲ and ゴトウ, コウセイ}
}