@article{oai:kumadai.repo.nii.ac.jp:00027315,
 author = {島田, 秀昭 and Shimada, Hideaki and 大田黒, 弥紗 and 三浦, かずみ and 今村, 順茂 and Imamura, Yorishige and 島田, 秀昭 and Shimada, Hideaki and Ohtaguro, Misa and Miura, Kazumi and 今村, 順茂 and Imamura, Yorishige},
 issue = {4},
 journal = {Journal of Enzyme Inhibition and Medicinal Chemistry},
 month = {Aug},
 note = {application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, 論文(Article), The inhibitory effects of diesel exhaust components and flavonoids on 20α-hydroxysteroid dehydrogenase (20α-HSD) activity were examined in cytosolic fractions from the liver, kidney and lung of male mice. 9,10-Phenanthrenequinone (9,10-PQ) and 1,2-naphthoquinone (1,2-NQ), which are contained in diesel exhaust particles (DEPs), potently inhibited 20α-HSD activity in liver cytosol. 9,10-PQ also inhibited the enzyme activity in lung cytosol. However, 20α-HSD activity in kidney cytosol was little inhibited by 9,10-PQ or 1,2-NQ. Flavonoids such as quercetin, fisetin and kaempferol exhibited high inhibitory potencies for 20α-HSD activity in liver cytosol, whereas these flavonoids were poor inhibitors for the enzyme activity in kidney cytosol. It is likely that several diesel exhaust components and flavonoids augment the signaling of progesterone in the liver cells, by inhibiting potently 20α-HSD activity in mouse liver cytosol. The possibility that there are distinct enzymes catalyzing 20α-HSD activity in non-reproductive tissues of male mice is also discussed., http://informahealthcare.com/doi/abs/10.1080/14756360601162113},
 pages = {445--449},
 title = {Inhibitory effects of diesel exhaust components and flavonoids on 20α-hydroxysteroid dehydrogenase activity in mouse tissues},
 volume = {22},
 year = {2007},
 yomi = {シマダ, ヒデアキ and イマムラ, ヨリシゲ and シマダ, ヒデアキ and イマムラ, ヨリシゲ}
}