@article{oai:kumadai.repo.nii.ac.jp:00027317,
 author = {今村, 順茂 and Imamura, Yorishige and 鳴海, 里加 and 島田, 秀昭 and Shimada, Hideaki and 今村, 順茂 and Imamura, Yorishige and Narumi, Rika and 島田, 秀昭 and Shimada, Hideaki},
 issue = {1},
 journal = {Journal of Enzyme Inhibition and Medicinal Chemistry},
 month = {Feb},
 note = {application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, 論文(Article), The inhibitory effects of alkyl phenyl ketones on carbonyl reductase activity were examined in pig heart.  In this study, carbonyl reductase activity was estimated as the ability to reduce 4-benzoylpyridine to S(-)-α-phenyl-4-pyridylmethanol in the cytosolic fraction from pig heart (pig heart cytosol).  The order of their inhibitory potencies for the enzyme activity was hexanophenone > valerophenone > heptanophenone > butyrophenone > propiophenone.  The inhibitory potencies of acetophenone and nonanophenone were much lower.  A significant relationship was observed between Vmax/Km values for the reduction of alkyl phenyl ketones and their inhibitory potencies for carbonyl reductase activity in pig heart cytosol.  Furthermore, hexanophenone was a competitive inhibitor for the enzyme activity.  These results indicate that several alkyl phenyl ketones including hexanophenone inhibit carbonyl reductase activity in pig heart cytosol, by acting as substrate inhibitors., http://informahealthcare.com/doi/abs/10.1080/14756360600954023},
 pages = {105--109},
 title = {Inhibition of carbonyl reductase activity in pig heart by alkyl phenyl ketones},
 volume = {22},
 year = {2007},
 yomi = {イマムラ, ヨリシゲ and シマダ, ヒデアキ and イマムラ, ヨリシゲ and シマダ, ヒデアキ}
}