{"created":"2023-06-19T09:15:02.353707+00:00","id":27317,"links":{},"metadata":{"_buckets":{"deposit":"4004a155-3abf-4e90-88f2-260496d8d34a"},"_deposit":{"created_by":1,"id":"27317","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"27317"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00027317","sets":["399:444"]},"author_link":["147199","78310","147196"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"109","bibliographicPageStart":"105","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"Journal of Enzyme Inhibition and Medicinal Chemistry"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"今村, 順茂","creatorNameLang":"ja"},{"creatorName":"Imamura, Yorishige","creatorNameLang":"en"},{"creatorName":"イマムラ, ヨリシゲ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"今村","familyNameLang":"ja"},{"familyName":"Imamura","familyNameLang":"en"},{"familyName":"イマムラ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"順茂","givenNameLang":"ja"},{"givenName":"Yorishige","givenNameLang":"en"},{"givenName":"ヨリシゲ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"147196","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鳴海, 里加"}],"nameIdentifiers":[{"nameIdentifier":"147199","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"島田, 秀昭","creatorNameLang":"ja"},{"creatorName":"Shimada, Hideaki","creatorNameLang":"en"},{"creatorName":"シマダ, ヒデアキ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"島田","familyNameLang":"ja"},{"familyName":"Shimada","familyNameLang":"en"},{"familyName":"シマダ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"秀昭","givenNameLang":"ja"},{"givenName":"Hideaki","givenNameLang":"en"},{"givenName":"ヒデアキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"78310","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The inhibitory effects of alkyl phenyl ketones on carbonyl reductase activity were examined in pig heart.  In this study, carbonyl reductase activity was estimated as the ability to reduce 4-benzoylpyridine to S(-)-α-phenyl-4-pyridylmethanol in the cytosolic fraction from pig heart (pig heart cytosol).  The order of their inhibitory potencies for the enzyme activity was hexanophenone > valerophenone > heptanophenone > butyrophenone > propiophenone.  The inhibitory potencies of acetophenone and nonanophenone were much lower.  A significant relationship was observed between Vmax/Km values for the reduction of alkyl phenyl ketones and their inhibitory potencies for carbonyl reductase activity in pig heart cytosol.  Furthermore, hexanophenone was a competitive inhibitor for the enzyme activity.  These results indicate that several alkyl phenyl ketones including hexanophenone inhibit carbonyl reductase activity in pig heart cytosol, by acting as substrate inhibitors.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://informahealthcare.com/doi/abs/10.1080/14756360600954023","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Informa 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