{"created":"2023-06-19T09:15:02.532511+00:00","id":27321,"links":{},"metadata":{"_buckets":{"deposit":"eba049db-fa74-43d8-99fd-a8611bf81fcd"},"_deposit":{"created_by":1,"id":"27321","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"27321"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00027321","sets":["399:444"]},"author_link":["147196","147518","78310"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-08-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"154","bibliographicPageStart":"148","bibliographicVolumeNumber":"155","bibliographic_titles":[{"bibliographic_title":"Chemico-Biological Interactions"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"荻沼, 道子"}],"nameIdentifiers":[{"nameIdentifier":"147518","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"島田, 秀昭","creatorNameLang":"ja"},{"creatorName":"Shimada, Hideaki","creatorNameLang":"en"},{"creatorName":"シマダ, ヒデアキ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"島田","familyNameLang":"ja"},{"familyName":"Shimada","familyNameLang":"en"},{"familyName":"シマダ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"秀昭","givenNameLang":"ja"},{"givenName":"Hideaki","givenNameLang":"en"},{"givenName":"ヒデアキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"78310","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"今村, 順茂","creatorNameLang":"ja"},{"creatorName":"Imamura, Yorishige","creatorNameLang":"en"},{"creatorName":"イマムラ, ヨリシゲ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"今村","familyNameLang":"ja"},{"familyName":"Imamura","familyNameLang":"en"},{"familyName":"イマムラ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"順茂","givenNameLang":"ja"},{"givenName":"Yorishige","givenNameLang":"en"},{"givenName":"ヨリシゲ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"147196","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The effects of adrenochrome, a metabolite of epinephrine (adrenaline), and 9,10-phenanthrenequinone (PQ), a component of diesel exhaust particles, on the stereoselective reduction of 4-benzoylpyridine (4-BP) were examined in pig heart cytosol.  PQ was a potent inhibitor for the 4-BP reduction, while adrenochrome was a poor inhibitor.  A similar result was observed in the effects of adrenochrome and PQ on the reduction of all-trans retinal.  Furthermore, although PQ mediated efficiently the formation of superoxide anion radical through its redox cycling in pig heart cytosol, adrenochrome had no ability to mediate the superoxide formation.  These may be because the reactivity for adrenochrome, catalyzed by pig heart carbonyl reductase (PHCR), is much lower than that for PQ.  The optimal pH for the reduction of PQ in pig heart cytosol was around 5.5.  Dicumarol, a potent inhibitor of DT-diaphorase, had little effect on the time course of NADPH oxidation during the reduction of PQ.  Therefore, it is concluded that PHCR plays a critical role in superoxide formation through redox cycling of PQ.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science/article/pii/S0009279705001717","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Ireland 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