{"created":"2023-06-19T09:15:03.033767+00:00","id":27329,"links":{},"metadata":{"_buckets":{"deposit":"768f1dfe-e06f-427a-b12f-b753e4d0202e"},"_deposit":{"created_by":12,"id":"27329","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"27329"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00027329","sets":["399:444"]},"author_link":["78310","147513","147512","147514","147507","147196","149938"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"67","bibliographicPageStart":"59","bibliographicVolumeNumber":"202","bibliographic_titles":[{"bibliographic_title":"Toxicology and Applied Pharmacology","bibliographic_titleLang":"en"}]}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The Long-Evans Cinnamon (LEC) rat is a mutant strain that accumulates excessive tissue copper (Cu) and models the clinical symptoms and biological features of Wilson’s disease in humans.  We compared the effects of three metal chelating agents, N-benzyl-D-glucamine dithiocarbamate (BGD), D-penicillamine (D-PEN), and triethylenetetramine (TETA) on the biliary and urinary excretions of Cu using LEC rats.  The animals were treated ip with each chelating agent (1 mmol/kg body weight) and then the bile and urine samples were collected for 3 h.  Since the single treatment with BGD markedly stimulated biliary excretion of Cu, the protective effect of repeated BGD injection on spontaneous hepatocellular damage was further examined.  Separate groups received two weekly injections of BGD starting at 11 weeks of age and were compared to saline injected controls.  Serum alanine aminotransferase (ALT) activity and bilirubin level were significantly increased in control LEC rats by 19 weeks of age and histopathological analysis demonstrated extensive hepatic damage in these rats.  However, repeated BGD injections prevented the increases in serum ALT and bilirubin and blocked the histopathological changes in the liver.  Furthermore, although Cu rapidly accumulated in the liver, kidney, spleen and serum of control LEC rats during the test period, repeated BGD injection largely prevented these increases.  These results indicate that BGD treatment is effective in blocking excessive Cu accumulation in LEC rats which, in turn, provides protection from spontaneous liver damage.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Academic Press Inc.","subitem_publisher_language":"en"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.taap.2004.06.005","subitem_relation_type_select":"DOI"}}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2005 Academic Press Inc."}]},"item_16_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0041-008X","subitem_source_identifier_type":"PISSN"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_16_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimada, Hideaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"78310","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Makiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"147513","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Akinori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"147512","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okawara, Tadashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"147514","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasutake, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"147507","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imamura, Yorishige","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"147196","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kiyozumi, Morio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"149938","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Fig8.pdf","filesize":[{"value":"10.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Fig8.pdf","url":"https://kumadai.repo.nii.ac.jp/record/27329/files/Fig8.pdf"},"version_id":"d26df04d-578d-452d-94ca-e2398dccfa5d"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Fig7.pdf","filesize":[{"value":"11.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Fig7.pdf","url":"https://kumadai.repo.nii.ac.jp/record/27329/files/Fig7.pdf"},"version_id":"be878d7a-8983-44a6-81a3-a014f81f6a24"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Fig6.pdf","filesize":[{"value":"10.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Fig6.pdf","url":"https://kumadai.repo.nii.ac.jp/record/27329/files/Fig6.pdf"},"version_id":"9b8f620e-1fee-49f6-8685-b4e8f10f7013"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Fig5.pdf","filesize":[{"value":"122.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Fig5.pdf","url":"https://kumadai.repo.nii.ac.jp/record/27329/files/Fig5.pdf"},"version_id":"45b8d3aa-9cdb-474d-bbae-dd24248cc1f9"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Fig4.pdf","filesize":[{"value":"10.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Fig4.pdf","url":"https://kumadai.repo.nii.ac.jp/record/27329/files/Fig4.pdf"},"version_id":"b77edaec-9362-4d02-af7e-851deca3c457"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Fig3.pdf","filesize":[{"value":"10.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Fig3.pdf","url":"https://kumadai.repo.nii.ac.jp/record/27329/files/Fig3.pdf"},"version_id":"a2788bac-83a6-4143-864e-6805ea76a076"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Fig2.pdf","filesize":[{"value":"7.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Fig2.pdf","url":"https://kumadai.repo.nii.ac.jp/record/27329/files/Fig2.pdf"},"version_id":"8231233c-767a-455b-9d69-746ccdbac117"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Fig1.pdf","filesize":[{"value":"7.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Fig1.pdf","url":"https://kumadai.repo.nii.ac.jp/record/27329/files/Fig1.pdf"},"version_id":"d87ea9c6-f159-4877-a44f-18d0a66bb994"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"TAP.202.59-67.pdf","filesize":[{"value":"85.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"TAP.202.59-67.pdf","url":"https://kumadai.repo.nii.ac.jp/record/27329/files/TAP.202.59-67.pdf"},"version_id":"209aedd9-e1e6-4575-9b33-82bafc1d55e4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Long-Evans Cinnamon rats","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"N-benzyl-D-glucamine dithiocarbamate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Wilson's disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Protection from spontaneous hepatocellular damage by N-benzyl-D-glucamine dithiocarbamate in Long-Evans Cinnamon rats, an animal model of Wilson's disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Protection from spontaneous hepatocellular damage by N-benzyl-D-glucamine dithiocarbamate in Long-Evans Cinnamon rats, an animal model of Wilson's disease","subitem_title_language":"en"}]},"item_type_id":"16","owner":"12","path":["444"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-03-13"},"publish_date":"2013-03-13","publish_status":"0","recid":"27329","relation_version_is_last":true,"title":["Protection from spontaneous hepatocellular damage by N-benzyl-D-glucamine dithiocarbamate in Long-Evans Cinnamon rats, an animal model of Wilson's disease"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-10-27T04:45:21.995790+00:00"}