@article{oai:kumadai.repo.nii.ac.jp:00027335,
 author = {島田, 秀昭 and Shimada, Hideaki and 高群, 泰隆 and 島田, 章則 and 安武, 章 and Waalkes, Michael P. and Waalkes, Michael P. and 島田, 秀昭 and Shimada, Hideaki and Takamure, Yasutaka and Shimada, Akinori and Yasutake, Akira and Waalkes, Michael P. and Waalkes, Michael P. and 今村, 順茂 and Imamura, Yorishige},
 issue = {1-3},
 journal = {Toxicology},
 month = {Oct},
 note = {application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, application/pdf, 論文(Article), We previously reported that Wistar-Imamichi (WI) rats have a strong resistance to cadmium (Cd)-induced lethality compared to other strains such as Fischer 344 (Fischer) rats.  The present study was designed to establish biochemical and histological differences in Cd toxicity in WI and Fischer rats, and to clarify the mechanistic basis of these strain differences.  A single Cd (4.5 mg/kg, s.c.) treatment caused a significant increase in serum alanine aminotransferase activity, indicative of hepatotoxicity, in Fischer rats, but did not in WI rats.  This difference in hepatotoxic response to Cd was supported by pathological analysis.  After treatment with Cd at doses of 3.0, 3.5 and 4.5 mg/kg, the hepatic and renal accumulation of Cd was significantly lower in the WI rats than in the Fischer rats, indicating a kinetic mechanism for the observed strain differences in Cd toxicity.  Thus, the remarkable resistance to Cd-induced hepatotoxicity in WI rats is associated, at least in part, with a lower tissue accumulation of the metal.  Hepatic and renal zinc (Zn) contents after administration were similarly lower in WI than in Fischer rats.  When Zn was administered in combination with Cd to Fischer rats, it decreased Cd contents in the liver and kidney, and exhibited a significant protective effect against the toxicity of Cd.  We propose the possibility that Zn transporter plays an important role in the strain difference of Cd toxicity in WI and Fischer rats., http://www.sciencedirect.com/science/article/pii/S0300483X04003294},
 pages = {189--197},
 title = {Strain differences of cadmium-induced hepatotoxicity  in Wistar-Imamichi and Fischer 344 rats: involvement of  cadmium accumulation},
 volume = {203},
 year = {2004},
 yomi = {シマダ, ヒデアキ and シマダ, ヒデアキ and イマムラ, ヨリシゲ}
}