{"created":"2023-06-19T09:15:03.308604+00:00","id":27335,"links":{},"metadata":{"_buckets":{"deposit":"7ae5eb59-2bb4-4fe4-9383-6773ee96cbad"},"_deposit":{"created_by":1,"id":"27335","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"27335"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00027335","sets":["399:444"]},"author_link":["78310","147508","147507","147196","147512","147511"],"item_15_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-10-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-3","bibliographicPageEnd":"197","bibliographicPageStart":"189","bibliographicVolumeNumber":"203","bibliographic_titles":[{"bibliographic_title":"Toxicology"}]}]},"item_15_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"島田, 秀昭","creatorNameLang":"ja"},{"creatorName":"Shimada, Hideaki","creatorNameLang":"en"},{"creatorName":"シマダ, ヒデアキ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"島田","familyNameLang":"ja"},{"familyName":"Shimada","familyNameLang":"en"},{"familyName":"シマダ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"秀昭","givenNameLang":"ja"},{"givenName":"Hideaki","givenNameLang":"en"},{"givenName":"ヒデアキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"78310","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高群, 泰隆"}],"nameIdentifiers":[{"nameIdentifier":"147511","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 章則"}],"nameIdentifiers":[{"nameIdentifier":"147512","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安武, 章"}],"nameIdentifiers":[{"nameIdentifier":"147507","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Waalkes, Michael P.","creatorNameLang":"en"},{"creatorName":"Waalkes, Michael P.","creatorNameLang":"ja"}],"familyNames":[{"familyName":"Waalkes","familyNameLang":"en"},{"familyName":"Waalkes","familyNameLang":"ja"}],"givenNames":[{"givenName":"Michael P.","givenNameLang":"en"},{"givenName":"Michael P.","givenNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"147508","nameIdentifierScheme":"WEKO"}]}]},"item_15_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_15_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_15_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"We previously reported that Wistar-Imamichi (WI) rats have a strong resistance to cadmium (Cd)-induced lethality compared to other strains such as Fischer 344 (Fischer) rats.  The present study was designed to establish biochemical and histological differences in Cd toxicity in WI and Fischer rats, and to clarify the mechanistic basis of these strain differences.  A single Cd (4.5 mg/kg, s.c.) treatment caused a significant increase in serum alanine aminotransferase activity, indicative of hepatotoxicity, in Fischer rats, but did not in WI rats.  This difference in hepatotoxic response to Cd was supported by pathological analysis.  After treatment with Cd at doses of 3.0, 3.5 and 4.5 mg/kg, the hepatic and renal accumulation of Cd was significantly lower in the WI rats than in the Fischer rats, indicating a kinetic mechanism for the observed strain differences in Cd toxicity.  Thus, the remarkable resistance to Cd-induced hepatotoxicity in WI rats is associated, at least in part, with a lower tissue accumulation of the metal.  Hepatic and renal zinc (Zn) contents after administration were similarly lower in WI than in Fischer rats.  When Zn was administered in combination with Cd to Fischer rats, it decreased Cd contents in the liver and kidney, and exhibited a significant protective effect against the toxicity of Cd.  We propose the possibility that Zn transporter plays an important role in the strain difference of Cd toxicity in WI and Fischer rats.","subitem_description_type":"Other"}]},"item_15_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science/article/pii/S0300483X04003294","subitem_description_type":"Other"}]},"item_15_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Ireland Ltd"}]},"item_15_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"15363594","subitem_relation_type_select":"PMID"}}]},"item_15_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.tox.2004.06.012","subitem_relation_type_select":"DOI"}}]},"item_15_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2004 Elsevier Ireland Ltd"}]},"item_15_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0300483X","subitem_source_identifier_type":"ISSN"}]},"item_15_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_15_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"55459 bytes"},{"subitem_text_value":"7511 bytes"},{"subitem_text_value":"137893 bytes"},{"subitem_text_value":"8419 bytes"},{"subitem_text_value":"6954 bytes"},{"subitem_text_value":"8329 bytes"},{"subitem_text_value":"7581 bytes"},{"subitem_text_value":"7570 bytes"},{"subitem_text_value":"8598 bytes"}]},"item_15_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"紀要論文"}]},"item_15_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Departmental Bulletin Paper"}]},"item_15_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_15_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"02"}]},"item_15_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"島田, 秀昭","creatorNameLang":"ja"},{"creatorName":"Shimada, Hideaki","creatorNameLang":"en"},{"creatorName":"シマダ, ヒデアキ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"島田","familyNameLang":"ja"},{"familyName":"Shimada","familyNameLang":"en"},{"familyName":"シマダ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"秀昭","givenNameLang":"ja"},{"givenName":"Hideaki","givenNameLang":"en"},{"givenName":"ヒデアキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"78310","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takamure, Yasutaka"}],"nameIdentifiers":[{"nameIdentifier":"147511","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Akinori"}],"nameIdentifiers":[{"nameIdentifier":"147512","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasutake, Akira"}],"nameIdentifiers":[{"nameIdentifier":"147507","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Waalkes, Michael P.","creatorNameLang":"en"},{"creatorName":"Waalkes, Michael P.","creatorNameLang":"ja"}],"familyNames":[{"familyName":"Waalkes","familyNameLang":"en"},{"familyName":"Waalkes","familyNameLang":"ja"}],"givenNames":[{"givenName":"Michael P.","givenNameLang":"en"},{"givenName":"Michael P.","givenNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"147508","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"今村, 順茂","creatorNameLang":"ja"},{"creatorName":"Imamura, Yorishige","creatorNameLang":"en"},{"creatorName":"イマムラ, ヨリシゲ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"今村","familyNameLang":"ja"},{"familyName":"Imamura","familyNameLang":"en"},{"familyName":"イマムラ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"順茂","givenNameLang":"ja"},{"givenName":"Yorishige","givenNameLang":"en"},{"givenName":"ヨリシゲ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"147196","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Fig8.pdf","filesize":[{"value":"8.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Fig8.pdf","url":"https://kumadai.repo.nii.ac.jp/record/27335/files/Fig8.pdf"},"version_id":"594c45e7-b2a6-4375-b324-dac122dec3cb"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Fig7.pdf","filesize":[{"value":"7.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Fig7.pdf","url":"https://kumadai.repo.nii.ac.jp/record/27335/files/Fig7.pdf"},"version_id":"4d79992f-3773-46a8-8bd8-62f587e872c8"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Fig6.pdf","filesize":[{"value":"7.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Fig6.pdf","url":"https://kumadai.repo.nii.ac.jp/record/27335/files/Fig6.pdf"},"version_id":"c0842784-347b-46e9-b22e-2f2bb008452e"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Fig5.pdf","filesize":[{"value":"8.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Fig5.pdf","url":"https://kumadai.repo.nii.ac.jp/record/27335/files/Fig5.pdf"},"version_id":"7e9e4151-f6ef-4277-8ebd-d6408df25715"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Fig4.pdf","filesize":[{"value":"7.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Fig4.pdf","url":"https://kumadai.repo.nii.ac.jp/record/27335/files/Fig4.pdf"},"version_id":"5157ce4a-55d9-4f01-80db-d540f6a2dd9a"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Fig3.pdf","filesize":[{"value":"8.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Fig3.pdf","url":"https://kumadai.repo.nii.ac.jp/record/27335/files/Fig3.pdf"},"version_id":"8428a25e-1f33-4423-97ac-298906bfb9f1"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Fig2.pdf","filesize":[{"value":"137.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Fig2.pdf","url":"https://kumadai.repo.nii.ac.jp/record/27335/files/Fig2.pdf"},"version_id":"1c646028-e4d7-410e-b42a-d9d3ae72944c"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Fig1.pdf","filesize":[{"value":"7.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Fig1.pdf","url":"https://kumadai.repo.nii.ac.jp/record/27335/files/Fig1.pdf"},"version_id":"0e9b96b4-e32f-455d-9d52-f7704ebb64ac"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Toxicology.203.189-197.pdf","filesize":[{"value":"55.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Toxicology.203.189-197.pdf","url":"https://kumadai.repo.nii.ac.jp/record/27335/files/Toxicology.203.189-197.pdf"},"version_id":"fb9831ed-517e-4113-a6d4-4c252cd55b68"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cadmium toxicity","subitem_subject_scheme":"Other"},{"subitem_subject":"Strain difference","subitem_subject_scheme":"Other"},{"subitem_subject":"Tissue accumulation","subitem_subject_scheme":"Other"},{"subitem_subject":"Rat","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Strain differences of cadmium-induced hepatotoxicity  in Wistar-Imamichi and Fischer 344 rats: involvement of  cadmium accumulation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Strain differences of cadmium-induced hepatotoxicity  in Wistar-Imamichi and Fischer 344 rats: involvement of  cadmium accumulation"}]},"item_type_id":"15","owner":"1","path":["444"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-03-13"},"publish_date":"2013-03-13","publish_status":"0","recid":"27335","relation_version_is_last":true,"title":["Strain differences of cadmium-induced hepatotoxicity  in Wistar-Imamichi and Fischer 344 rats: involvement of  cadmium accumulation"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-08-18T03:08:11.408927+00:00"}