@article{oai:kumadai.repo.nii.ac.jp:00027692,
 author = {吉川, 裕美 and 清水, 英介 and 川原, 浩一 and 國安, 明彦 and 芝野, 俊郎 and 中山, 仁 and Yoshikawa, Hiromi and Shimizu, Eisuke and Kawahara, Kohichi and Kuniyasu, Akihiko and Shibano, Toshiro and 中山, 仁 and Nakayama, Hitoshi},
 issue = {2},
 journal = {Heterocycles},
 month = {},
 note = {application/pdf, 論文(Article), To clarify the recognition site of (S)-semotiadil in the Na+ channels,
we employed photoaffinity labeling with (S)-[3H]-D51-4700, an azidophenyl
derivative of (S)-semotiadil, to Na+ channel preparations from rat brains and
porcine hearts, and the results were compared with those by (R)-enantiomer to
skeletal muscle Ca2+ channel. Protease-digestion of the photolabeled Na+ channels
followed by quantitative immunoprecipitation assay using a site-directed
antibody, revealed that 10- and 13- kDa fargments of brain and cardiac Na+
channels, respectively, were located within the regions including IVS6. These
regions are corresponding to the 8.3 kDa fragment photolabled by (R)-[3H]-D51-
4700 in the skeletal muscle Ca2+ channel. Interestingly, however, the
photoincorporation of (S)-[3H]-D51-4700 into the Na+ channel was 2-3 times
higher than that of (R)-isomer; and visa versa in the Ca2+ channels., http://www.heterocycles.jp/newlibrary/libraries/abst/00997},
 pages = {613--622},
 title = {Photochemical identification of the binding region for (S)-semotiadil on sodium channels: Comparison with that for (R)-semotiadil on skeletal muscle calcium channel},
 volume = {59},
 year = {2003},
 yomi = {ナカヤマ, ヒトシ}
}