{"created":"2023-06-19T09:15:20.681886+00:00","id":27692,"links":{},"metadata":{"_buckets":{"deposit":"68deccfd-e2cc-4527-997b-8d5d9f146c99"},"_deposit":{"created_by":1,"id":"27692","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"27692"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00027692","sets":["415:416"]},"author_link":["125204","125194","125202","125193","125206","125207","125190","125203","125205","125191","125192","92194"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"622","bibliographicPageStart":"613","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"Heterocycles"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉川, 裕美"}],"nameIdentifiers":[{"nameIdentifier":"125202","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"清水, 英介"}],"nameIdentifiers":[{"nameIdentifier":"125203","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川原, 浩一"}],"nameIdentifiers":[{"nameIdentifier":"125204","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"國安, 明彦"}],"nameIdentifiers":[{"nameIdentifier":"125205","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"芝野, 俊郎"}],"nameIdentifiers":[{"nameIdentifier":"125206","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中山, 仁"}],"nameIdentifiers":[{"nameIdentifier":"125207","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"To clarify the recognition site of (S)-semotiadil in the Na+ channels,\nwe employed photoaffinity labeling with (S)-[3H]-D51-4700, an azidophenyl\nderivative of (S)-semotiadil, to Na+ channel preparations from rat brains and\nporcine hearts, and the results were compared with those by (R)-enantiomer to\nskeletal muscle Ca2+ channel. Protease-digestion of the photolabeled Na+ channels\nfollowed by quantitative immunoprecipitation assay using a site-directed\nantibody, revealed that 10- and 13- kDa fargments of brain and cardiac Na+\nchannels, respectively, were located within the regions including IVS6. These\nregions are corresponding to the 8.3 kDa fragment photolabled by (R)-[3H]-D51-\n4700 in the skeletal muscle Ca2+ channel. Interestingly, however, the\nphotoincorporation of (S)-[3H]-D51-4700 into the Na+ channel was 2-3 times\nhigher than that of (R)-isomer; and visa versa in the Ca2+ channels.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.heterocycles.jp/newlibrary/libraries/abst/00997","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japan Institute of Heterocyclic Chemistry"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3987/COM-02-S62","subitem_relation_type_select":"DOI"}}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2002 The Japan Institute of Heterocyclic Chemistry"}]},"item_16_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1881-0942","subitem_source_identifier_type":"ISSN"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"430","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"229218 bytes"}]},"item_16_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_16_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal 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Toshiro"}],"nameIdentifiers":[{"nameIdentifier":"125194","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"中山, 仁","creatorNameLang":"ja"},{"creatorName":"ナカヤマ, ヒトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakayama, Hitoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"中山","familyNameLang":"ja"},{"familyName":"ナカヤマ","familyNameLang":"ja-Kana"},{"familyName":"Nakayama","familyNameLang":"en"}],"givenNames":[{"givenName":"仁","givenNameLang":"ja"},{"givenName":"ヒトシ","givenNameLang":"ja-Kana"},{"givenName":"Hitoshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92194","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"COM-02-S62.pdf","filesize":[{"value":"229.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"COM-02-S62.pdf","url":"https://kumadai.repo.nii.ac.jp/record/27692/files/COM-02-S62.pdf"},"version_id":"7db72fd1-addd-4c5b-9f22-6ece422e5b91"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Photochemical identification of the binding region for (S)-semotiadil on sodium channels: Comparison with that for (R)-semotiadil on skeletal muscle calcium channel","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Photochemical identification of the binding region for (S)-semotiadil on sodium channels: Comparison with that for (R)-semotiadil on skeletal muscle calcium channel"}]},"item_type_id":"16","owner":"1","path":["416"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-06-04"},"publish_date":"2013-06-04","publish_status":"0","recid":"27692","relation_version_is_last":true,"title":["Photochemical identification of the binding region for (S)-semotiadil on sodium channels: Comparison with that for (R)-semotiadil on skeletal muscle calcium channel"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-09-13T05:01:18.835012+00:00"}